Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03682757 · ClinicalTrials.gov registry record
Post-Injury Platelet Biology: Mechanisms and Outcomes
A clinical trial, sponsored by University of California, San Francisco.
- Completed
- Registry status
- 367
- Enrollment target
NCT03682757: Completed study, sponsored by University of California, San Francisco.
NCT03682757 is a clinical trial that has completed, run by University of California, San Francisco. The registered enrollment target is 367 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03682757 has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- 367 participants
- Enrollment target
Study Summary
Trauma-induced coagulopathy is a central cause of preventable deaths from hemorrhage after injury. The contribution and impact of altered post injury platelet biology on trauma-induced coagulopathy is not well understood despite the pivotal contribution of platelets to normal coagulation and endothelial integrity. The central hypothesis for this study is that severe injury and shock drive altered platelet activation, platelet aggregation, and platelet-endothelial interactions that are associated with increased rates of transfusion, organ failure, and mortality. This study will investigate these causal pathways, mechanisms, and associated outcomes in a prospective observational trauma cohort through collection of biospecimens and detailed clinical data.
Primary Outcome
Plasma biomarkers of endothelial injury will be measured by enzyme-linked immunosorbent assays (von Willebrand factor, syndecan-1, and angiopoietin-2).
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 367 participants |
| Start Date | 2018-09-20 |
| Est. Completion | 2023-09-30 |
What the finished NCT03682757 record still lists
NCT03682757 is an observational study that tracks outcomes without assigning an intervention. The registered 367 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT03682757 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03682757 about?
NCT03682757 is a clinical study titled "Post-Injury Platelet Biology: Mechanisms and Outcomes". Trauma-induced coagulopathy is a central cause of preventable deaths from hemorrhage after injury. The contribution and impact of altered post injury platelet biology on trauma-induced coagulopathy is not well understood despite the pivotal contribution of platelets to normal coagulation and endothe...
What is the current status of trial NCT03682757?
This trial is currently completed. The enrollment target is 367 participants. The study started on 2018-09-20. Estimated completion is 2023-09-30.
Who is sponsoring clinical trial NCT03682757?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04675476 · 368 participants · NA
A Patient and Provider Intervention to Address Health Disparities in Lung Cancer Screening
- NCT05215353 · 368 participants · Phase 4
A Study Comparing Music Therapy and Cognitive Behavioral Therapy for Anxiety in Cancer Survivors
- NCT06182397 · 368 participants · NA
Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease
- NCT06629610 · 368 participants · NA
Diet and Active Lifestyle - Yuuyaraq (The Yup'ik Way of Life)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI