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NCT03680638 · ClinicalTrials.gov registry record · Phase 1
The Effect of Antioxidants on Skin Blood Flow During Local Heating
A Phase 1 study, sponsored by The University of Texas at Arlington.
- Completed
- Registry status
- Phase 1
- Development phase
- 44
- Enrollment target
NCT03680638: Completed Phase 1 study, sponsored by The University of Texas at Arlington.
NCT03680638 is a Phase 1 study that has completed, run by The University of Texas at Arlington. The registered enrollment target is 44 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (27% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03680638, a Phase 1 study, has completed, sponsored by The University of Texas at Arlington.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 44 participants
- Enrollment target
Study Summary
The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.
Primary Outcome
Assess the impact of oxidative stress on impaired vasodilation to local heating. This will be elicited using intradermal microdialysis infusions of apocynin, allopurinol, or tempol, all of which are vasoactive substances. The changes in skin blood flux will be quantified using laser Doppler fluxmetry. All changes in flux will be normalized and reported as a percentage of maximal flux.
Interventions
- DRUG Allopurinol
- DRUG Tempol
- OTHER Control (Lactated Ringer's)
- DRUG Apocynin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2016-09-07 |
| Est. Completion | 2017-10-09 |
| Phase | Phase 1 |
What the finished NCT03680638 record still lists
NCT03680638 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (27% lower).
The record links to 0 conditions, and to 4 interventions - of which Allopurinol is the first listed.
NCT03680638 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03680638 about?
NCT03680638 is a clinical study titled "The Effect of Antioxidants on Skin Blood Flow During Local Heating". The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.
What is the current status of trial NCT03680638?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2016-09-07. Estimated completion is 2017-10-09.
What interventions are being tested in trial NCT03680638?
The interventions under investigation include: Allopurinol (DRUG), Tempol (DRUG), Control (Lactated Ringer's) (OTHER), Apocynin (DRUG).
Who is sponsoring clinical trial NCT03680638?
This trial is sponsored by The University of Texas at Arlington, which has 32 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03680638's enrollment target sits among peer trials
44 1086th of 2000 higher than 901 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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