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NCT03674047 · ClinicalTrials.gov registry record · Phase 2
Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)
A Phase 2 study of Other Cancer, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 7
- Study locations
NCT03674047: Active Phase 2 study of Other Cancer, sponsored by Massachusetts General Hospital.
NCT03674047 is a Phase 2 study of Other Cancer that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 50 participants, below the 3,257-participant average among 5 other Other Cancer trials with a reported enrollment target (98% lower). The trial reports 7 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03674047, a Phase 2 study of Other Cancer, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 7
- Study locations
Study Summary
This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT).
Primary Outcome
The proportion of participants with a sustained, absolute FEV1 increase by ≥ 10% after 3 months of treatment with ruxolitinib (compared to baseline measure prior to study enrollment) among participants with newly diagnosed Bronchiolitis Obliterans Syndrome BOS.
Conditions Studied
Interventions
- DRUG ruxolitinib
Study Locations (7)
California
- City of Hope Cancer Center - Duarte
Florida
- H. Lee Moffitt Cancer Center - Tampa
Massachusetts
- Massachusetts General Hospital - Boston
Ohio
- Cleveland Clinic - Cleveland
Utah
- Huntsman Cancer Institute - Salt Lake City
Washington
- Fred Hutchinson Cancer Center - Seattle
Wisconsin
- Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2019-04-19 |
| Est. Completion | 2025-12 |
| Phase | Phase 2 |
What the registry record for NCT03674047 still lists
NCT03674047 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 3,257-participant average among 5 other Other Cancer trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Other Cancer appearing as the primary indexed condition, and to 1 intervention - of which ruxolitinib is the first listed.
NCT03674047 lists 7 locations in 7 states (California, Florida, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT03674047 about?
NCT03674047 is a clinical study titled "Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)". This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT).
What is the current status of trial NCT03674047?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2019-04-19. Estimated completion is 2025-12.
What conditions does trial NCT03674047 study?
This clinical trial studies the following conditions: Other Cancer.
What interventions are being tested in trial NCT03674047?
The interventions under investigation include: ruxolitinib (DRUG).
Who is sponsoring clinical trial NCT03674047?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03674047 being conducted?
This trial has 7 study locations across California, Florida, Massachusetts, Ohio, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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