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NCT03653676 · ClinicalTrials.gov registry record
Sickle Cell Pro-Inflammatory Response to Interval Training Study
A clinical trial, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- Completed
- Registry status
- 110
- Enrollment target
NCT03653676: Completed study, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
NCT03653676 is a clinical trial that has completed, run by Ann & Robert H Lurie Children's Hospital of Chicago. The registered enrollment target is 110 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03653676 has completed, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- COMPLETED
- Registry status
- 110 participants
- Enrollment target
Study Summary
Recommendations for exercise prescription currently do not exist for individuals with sickle cell anemia (SCA) despite the known impact that SCA-related complications has on physical functioning and fitness. A major barrier to increasing physical activity in SCA is the concern that the well-described inflammatory effects of exercise could precipitate or exacerbate complications such as vaso-occlusive pain or airway bronchoconstriction (i.e. exercise-induced asthma). Although the investigator's preliminary data suggest that increasing physical activity may be beneficial rather than harmful in children with SCA, the pro-inflammatory effects associated with repeated bouts of moderate to vigorous exercise remain poorly understood in this population. The long term goal is to address the safety and health impact of regular exercise in children with SCA. This proposal would help establish the safety of moderate to vigorous intensity exercise in children with SCA and importantly, will inform the design of future clinical trials focused on exercise training as a transformative strategy to improve fitness and overall well-being in this population.
Primary Outcome
Change in soluble vascular cell adhesion molecule VCAM-1 in ng/mL
Interventions
- OTHER Exercise Test (CIIT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2018-01-02 |
| Est. Completion | 2023-03-17 |
What the finished NCT03653676 record still lists
NCT03653676 is an observational study that tracks outcomes without assigning an intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Exercise Test (CIIT) is the first listed.
NCT03653676 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03653676 about?
NCT03653676 is a clinical study titled "Sickle Cell Pro-Inflammatory Response to Interval Training Study". Recommendations for exercise prescription currently do not exist for individuals with sickle cell anemia (SCA) despite the known impact that SCA-related complications has on physical functioning and fitness. A major barrier to increasing physical activity in SCA is the concern that the well-describe...
What is the current status of trial NCT03653676?
This trial is currently completed. The enrollment target is 110 participants. The study started on 2018-01-02. Estimated completion is 2023-03-17.
What interventions are being tested in trial NCT03653676?
The interventions under investigation include: Exercise Test (CIIT) (OTHER).
Who is sponsoring clinical trial NCT03653676?
This trial is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total clinical trials registered on ClinicalTrials.gov.
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