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NCT03634007 · ClinicalTrials.gov registry record · Phase 1
Gene Therapy for APOE4 Homozygote of Alzheimer's Disease
A Phase 1 study, sponsored by Lexeo Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
NCT03634007: Completed Phase 1 study, sponsored by Lexeo Therapeutics.
NCT03634007 is a Phase 1 study that has completed, run by Lexeo Therapeutics. The registered enrollment target is 15 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03634007, a Phase 1 study, has completed, sponsored by Lexeo Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
Study Summary
This clinical trial is an open label, dose-ranging study designed to evaluate gene therapy to treat patients who are APOE4 homozygotes with clinical diagnosis varying from mild cognitive impairment due to Alzheimer's, mild dementia due to Alzheimer's disease, and moderate dementia due to Alzheimer's disease.
Primary Outcome
Adverse events categorized and graded
Interventions
- BIOLOGICAL LX1001
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2019-11-06 |
| Est. Completion | 2024-11-07 |
| Phase | Phase 1 |
What the finished NCT03634007 record still lists
NCT03634007 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower).
The record links to 0 conditions, and to 1 intervention - of which LX1001 is the first listed.
NCT03634007 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03634007 about?
NCT03634007 is a clinical study titled "Gene Therapy for APOE4 Homozygote of Alzheimer's Disease". This clinical trial is an open label, dose-ranging study designed to evaluate gene therapy to treat patients who are APOE4 homozygotes with clinical diagnosis varying from mild cognitive impairment due to Alzheimer's, mild dementia due to Alzheimer's disease, and moderate dementia due to Alzheimer's...
What is the current status of trial NCT03634007?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2019-11-06. Estimated completion is 2024-11-07.
What interventions are being tested in trial NCT03634007?
The interventions under investigation include: LX1001 (BIOLOGICAL).
Who is sponsoring clinical trial NCT03634007?
This trial is sponsored by Lexeo Therapeutics, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03634007's enrollment target sits among peer trials
15 1798th of 2000 higher than 157 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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