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NCT03629990 · ClinicalTrials.gov registry record · NA
Approach Bias Modification for the Treatment of Cannabis Use Disorder
A NA study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- NA
- Development phase
- 104
- Enrollment target
NCT03629990 is a NA study that has completed, run by Medical University of South Carolina. The registered enrollment target is 104 participants.
The verdict
NCT03629990, a NA study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- NA
- Development phase
- 104 participants
- Enrollment target
Study Summary
Effective and durable treatments for cannabis use disorder remain elusive. Given the increasing prevalence rates of cannabis use and CUD nationwide, investigation of novel treatments is warranted. Implicit cognitive processing is an emerging, and potentially critical therapeutic target. Cognitive models of addiction posit an override of explicit control-related cognitive processes by implicit reward-driven processes resulting from chronic drug exposure. One form of implicit cognitive processing is approach bias, or, the automatic tendency to approach rather than avoid drug cues, which has been identified for alcohol, nicotine, opioids, and cannabis. Cannabis approach bias predicts increased cannabis use, dependence severity, and cannabis-related problems among heavy cannabis users. Approach bias modification (ABM) is a novel treatment approach that seeks to reduce approach bias by attenuating the incentive-salience of drug cues, and subsequently, drug cue reactivity and drug use. ABM has been shown to reduce relapse rates in alcohol dependent adults by 10-13% at one-year follow-up, and dependence severity in nicotine dependent adults. Our pilot data suggests that ABM may also reduce cannabis craving and that gender may moderate the effect of ABM on cannabis sessions per day in non-treatment seeking adults with CUD. A recent fMRI study with alcohol-dependent adults found decreased mesolimbic activation in participants who received ABM compared to sham-control participants. ABM appears to target implicit reward-driven processes, and could be an effective adjunct to traditional psychosocial and/or future pharmacological interventions that target explicit control-related processes. Building on our promising feasibility data, the proposed K23 research study will examine the effects of ABM on cue-reactivity and cannabis outcomes in a four-session randomized, double-blind, sham-controlled pilot treatment trial. One-hundred and six (106) treatment-seeking adults with mode
Interventions
- BEHAVIORAL Approach Bias Modification (ABM)
- BEHAVIORAL Sham ABM
- BEHAVIORAL Psychosocial therapy for cannabis use disorder.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 104 participants |
| Start Date | 2019-01-16 |
| Est. Completion | 2023-10-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03629990
The ClinicalTrials.gov registry entry for NCT03629990 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 104 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Approach Bias Modification (ABM) is the first listed.
NCT03629990 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03629990 about?
NCT03629990 is a clinical study titled "Approach Bias Modification for the Treatment of Cannabis Use Disorder". Effective and durable treatments for cannabis use disorder remain elusive. Given the increasing prevalence rates of cannabis use and CUD nationwide, investigation of novel treatments is warranted. Implicit cognitive processing is an emerging, and potentially critical therapeutic target. Cognitive m...
What is the current status of trial NCT03629990?
This trial is currently completed. It is a NA study. The enrollment target is 104 participants. The study started on 2019-01-16. Estimated completion is 2023-10-30.
What interventions are being tested in trial NCT03629990?
The interventions under investigation include: Approach Bias Modification (ABM) (BEHAVIORAL), Sham ABM (BEHAVIORAL), Psychosocial therapy for cannabis use disorder. (BEHAVIORAL).
Who is sponsoring clinical trial NCT03629990?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
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