Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03603899 · ClinicalTrials.gov registry record · Phase 1
Hp129 Xenon Imaging and BOS in Lung Transplantation
A Phase 1 study of Bronchiolitis Obliterans, sponsored by Children's Hospital Medical Center, Cincinnati.
- Completed
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
- 1
- Study location
NCT03603899: Completed Phase 1 study of Bronchiolitis Obliterans, sponsored by Children's Hospital Medical Center, Cincinnati.
NCT03603899 is a Phase 1 study of Bronchiolitis Obliterans that has completed, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 3 participants, below the 409-participant average among 9 other Bronchiolitis Obliterans trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03603899, a Phase 1 study of Bronchiolitis Obliterans, has completed, sponsored by Children's Hospital Medical Center, Cincinnati.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
- 1
- Study location
Study Summary
The research is being conducted to develop new imaging methods that are sufficiently sensitive to allow for early diagnosis of BOS, a chronic allograft rejection affecting 50-60% of lung transplanted recipients who survive 5 years after transplant. Although lung transplantation has evolved into an effective therapeutic option for a large number of pediatric patients with end-stage pulmonary disease, long-term survival after lung transplantation is far worse than after the transplantation of other solid organs. This research may improve patient outcomes through earlier diagnosis of changes leading to BOS by obtaining image guided research biopsies of transplanted lung. Biopsies may be used for future research of ex vivo biomarkers of BOS and in the development of treatments through future clinical trials.
Primary Outcome
Capture HP 129Xe and 1H MR images for clinician review for regional ventilation defects in post-transplant BOS patients during routine clinical visits
Conditions Studied
Interventions
- DRUG Hp 129Xenon
Study Locations (1)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2020-09-09 |
| Est. Completion | 2024-05-28 |
| Phase | Phase 1 |
What the finished NCT03603899 record still lists
NCT03603899 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 409-participant average among 9 other Bronchiolitis Obliterans trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Bronchiolitis Obliterans appearing as the primary indexed condition, and to 1 intervention - of which Hp 129Xenon is the first listed.
NCT03603899 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03603899 about?
NCT03603899 is a clinical study titled "Hp129 Xenon Imaging and BOS in Lung Transplantation". The research is being conducted to develop new imaging methods that are sufficiently sensitive to allow for early diagnosis of BOS, a chronic allograft rejection affecting 50-60% of lung transplanted recipients who survive 5 years after transplant. Although lung transplantation has evolved into an e...
What is the current status of trial NCT03603899?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2020-09-09. Estimated completion is 2024-05-28.
What conditions does trial NCT03603899 study?
This clinical trial studies the following conditions: Bronchiolitis Obliterans.
What interventions are being tested in trial NCT03603899?
The interventions under investigation include: Hp 129Xenon (DRUG).
Who is sponsoring clinical trial NCT03603899?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03603899 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Bronchiolitis Obliterans
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03603899's enrollment target sits among peer trials
3 10th of 9 the lowest of 9 other Bronchiolitis Obliterans trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bronchiolitis Obliterans trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Mesenchymal Stem Cell Therapy for Lung Rejection
COMPLETED · Phase 1
-
TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients
RECRUITING
-
BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
RECRUITING · Phase 2
-
Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome
RECRUITING
-
Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3)
ACTIVE NOT RECRUITING · Phase 3
-
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
COMPLETED · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI