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NCT03594448 · ClinicalTrials.gov registry record
Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma Patients
A clinical trial, sponsored by University of Southern California.
- Terminated
- Registry status
- 6
- Enrollment target
NCT03594448: Clinical Trial study, sponsored by University of Southern California.
NCT03594448 is a clinical trial that was terminated before completion, run by University of Southern California. The registered enrollment target is 6 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03594448 was terminated before completion, sponsored by University of Southern California.
- TERMINATED
- Registry status
- 6 participants
- Enrollment target
Study Summary
This pilot trial studies how well serial liquid biopsies work in detecting microsatellite instability in participants with stage IV colorectal cancer. Serial liquid biopsies may help doctors learn better methods to track cancer in the bloodstream and how to use these to improve cancer treatments.
Primary Outcome
MSI testing distinguishes between tumors into one of 3 phenotypic categories: MSI-High (MSI-H) is reported when \> 30% of biomarkers show instability; Microsatellite stable (MSS) is reported in the absence of instability. The third category, MSI-Low (MSI-L) is diagnostically equivalent to MSS, and is reported when MSI is present in \< 30% of biomarkers. MSI status will be determined by polymerase chain reaction (PCR) using commercial kits provided by Promega.
Interventions
- PROCEDURE Specimen Collection
- PROCEDURE Serial Liquid Biopsy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2018-09-05 |
| Est. Completion | 2023-09-18 |
Why NCT03594448 stopped before completion
NCT03594448 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 6 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Specimen Collection is the first listed.
NCT03594448 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03594448 about?
NCT03594448 is a clinical study titled "Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma Patients". This pilot trial studies how well serial liquid biopsies work in detecting microsatellite instability in participants with stage IV colorectal cancer. Serial liquid biopsies may help doctors learn better methods to track cancer in the bloodstream and how to use these to improve cancer treatments.
What is the current status of trial NCT03594448?
This trial is currently terminated. The enrollment target is 6 participants. The study started on 2018-09-05. Estimated completion is 2023-09-18.
What interventions are being tested in trial NCT03594448?
The interventions under investigation include: Specimen Collection (PROCEDURE), Serial Liquid Biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT03594448?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
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