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NCT03575273 · ClinicalTrials.gov registry record · NA
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT03575273: Completed NA study, sponsored by Johns Hopkins University.
NCT03575273 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 45 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03575273, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence. A notable phenomenon associated with MMT is increased food intake, enhanced sweet preferences, and weight gain. The underlying neural mechanisms for opioid-related overconsumption are not well understood but are thought to arise from role in 1) increasing the palatability and hedonic aspects of food and 2) diminishing satiety signaling systems. In the proposed project, the investigators will examine methadone's potential role in opioid-related overconsumption of food. The investigators propose to examine eating behavior, sucrose preferences, and an event-related potential (ERP) component that is induced by appetitive motivation for highly rewarding foods in patients with a history of opioid dependence receiving methadone maintenance therapy (O+MMT) and not receiving opioid agonist therapy (O-MMT). A matched sample of obese and overweight adults without history of opioid use (HOC) will also be examined.
Interventions
- BEHAVIORAL Sniffin' Sticks Odor Identification and Hedonic Scale
- BEHAVIORAL Sucrose Taste Preference Assessment
- BEHAVIORAL Food Preferences Task
- BEHAVIORAL Progressive Ratio (PR) Task
- PROCEDURE Clinical Electrophysiology
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2018-02-12 |
| Est. Completion | 2020-06-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03575273
The ClinicalTrials.gov registry entry for NCT03575273 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Sniffin' Sticks Odor Identification and Hedonic Scale is the first listed.
NCT03575273 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03575273 about?
NCT03575273 is a clinical study titled "The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence". Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence. A notable phenomenon associated with MMT is increased food intake, enhanced sweet preferences, and weight gain. The underlying neural m...
What is the current status of trial NCT03575273?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2018-02-12. Estimated completion is 2020-06-01.
What interventions are being tested in trial NCT03575273?
The interventions under investigation include: Sniffin' Sticks Odor Identification and Hedonic Scale (BEHAVIORAL), Sucrose Taste Preference Assessment (BEHAVIORAL), Food Preferences Task (BEHAVIORAL), Progressive Ratio (PR) Task (BEHAVIORAL), Clinical Electrophysiology (PROCEDURE).
Who is sponsoring clinical trial NCT03575273?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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