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NCT03575273 · ClinicalTrials.gov registry record · NA
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT03575273: Completed NA study, sponsored by Johns Hopkins University.
NCT03575273 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 45 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03575273, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence. A notable phenomenon associated with MMT is increased food intake, enhanced sweet preferences, and weight gain. The underlying neural mechanisms for opioid-related overconsumption are not well understood but are thought to arise from role in 1) increasing the palatability and hedonic aspects of food and 2) diminishing satiety signaling systems. In the proposed project, the investigators will examine methadone's potential role in opioid-related overconsumption of food. The investigators propose to examine eating behavior, sucrose preferences, and an event-related potential (ERP) component that is induced by appetitive motivation for highly rewarding foods in patients with a history of opioid dependence receiving methadone maintenance therapy (O+MMT) and not receiving opioid agonist therapy (O-MMT). A matched sample of obese and overweight adults without history of opioid use (HOC) will also be examined.
Primary Outcome
Cortical ERPs for high-reward food relative to low-reward food and non-food items will be measured using a BrainVision actiCHamp system (32-channel amplifier). For each group, the grand averages and standard deviations for the late positive potential will be calculated. Group differences in LPP will be assessed within and between picture categories for each arm of the study.
Interventions
- BEHAVIORAL Sniffin' Sticks Odor Identification and Hedonic Scale
- BEHAVIORAL Sucrose Taste Preference Assessment
- BEHAVIORAL Food Preferences Task
- BEHAVIORAL Progressive Ratio (PR) Task
- PROCEDURE Clinical Electrophysiology
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2018-02-12 |
| Est. Completion | 2020-06-01 |
| Phase | NA |
What the finished NCT03575273 record still lists
NCT03575273 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 5 interventions - of which Sniffin' Sticks Odor Identification and Hedonic Scale is the first listed.
NCT03575273 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03575273 about?
NCT03575273 is a clinical study titled "The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence". Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence. A notable phenomenon associated with MMT is increased food intake, enhanced sweet preferences, and weight gain. The underlying neural m...
What is the current status of trial NCT03575273?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2018-02-12. Estimated completion is 2020-06-01.
What interventions are being tested in trial NCT03575273?
The interventions under investigation include: Sniffin' Sticks Odor Identification and Hedonic Scale (BEHAVIORAL), Sucrose Taste Preference Assessment (BEHAVIORAL), Food Preferences Task (BEHAVIORAL), Progressive Ratio (PR) Task (BEHAVIORAL), Clinical Electrophysiology (PROCEDURE).
Who is sponsoring clinical trial NCT03575273?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03575273's enrollment target sits among peer trials
45 1411th of 2000 higher than 578 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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