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NCT03574857 · ClinicalTrials.gov registry record · Phase 4
Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance
A Phase 4 study, sponsored by University of Virginia.
- Terminated
- Registry status
- Phase 4
- Development phase
- 5
- Enrollment target
NCT03574857: Clinical Trial Phase 4 study, sponsored by University of Virginia.
NCT03574857 is a Phase 4 study that was terminated before completion, run by University of Virginia. The registered enrollment target is 5 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03574857, a Phase 4 study, was terminated before completion, sponsored by University of Virginia.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 5 participants
- Enrollment target
Study Summary
The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). This will be a single-center randomized pilot study.
Primary Outcome
Milliliters of urine output minus the oral plus intravenous intake
Interventions
- DRUG Metolazone Oral Tablet
- DRUG Chlorothiazide Injection
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2018-06-01 |
| Est. Completion | 2021-01-01 |
| Phase | Phase 4 |
Why NCT03574857 stopped before completion
NCT03574857 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Metolazone Oral Tablet is the first listed.
NCT03574857 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03574857 about?
NCT03574857 is a clinical study titled "Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance". The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). This will be a single-center randomized pilot study.
What is the current status of trial NCT03574857?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 5 participants. The study started on 2018-06-01. Estimated completion is 2021-01-01.
What interventions are being tested in trial NCT03574857?
The interventions under investigation include: Metolazone Oral Tablet (DRUG), Chlorothiazide Injection (DRUG).
Who is sponsoring clinical trial NCT03574857?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03574857's enrollment target sits among peer trials
5 1989th of 2000 higher than 7 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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