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NCT03528486 · ClinicalTrials.gov registry record · NA
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
A NA study, sponsored by University of South Florida.
- Completed
- Registry status
- NA
- Development phase
- 268
- Enrollment target
NCT03528486: Completed NA study, sponsored by University of South Florida.
NCT03528486 is a NA study that has completed, run by University of South Florida. The registered enrollment target is 268 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (81% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03528486, a NA study, has completed, sponsored by University of South Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 268 participants
- Enrollment target
Study Summary
Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious. It is also not clear when, along the continuum of normal cognitive aging to mild cognitive impairment (MCI-a transitional stage before dementia onset), it is most efficacious to intervene. This randomized clinical trial will determine the efficacy of a novel cognitive engagement intervention approach (music training) as compared to cognitive stimulation (which will serve as a stringent, active control). Grounded in theory, the central hypothesis is that interventions enhancing central auditory processing (CAP), a strong, longitudinal predictor of MCI and dementia, will improve cognition. Music training is increasingly recognized as a feasible means to attenuate age-related cognitive decline. Prior research and preliminary data suggest that intense piano training enhances CAP and is likely more effective than cognitive stimulation. Correlational studies indicate superior CAP, executive function, and other cognitive abilities for adults with formal music training compared to non-musicians. The specific aims of the study are to examine the efficacy of music training relative to cognitive stimulation (active controls) to improve CAP, cognition, and everyday function among older adults with and without MCI. The efficacy of music training will be established and moderating effects of MCI status will be examined. The proposed study further aims to elucidate the underlying mechanisms of effective cognitive intervention approaches by exploring mediators of training gains. The proposed study is the first phase II randomized trial of music training to enhance older adults' cognition. Mediation analyses will elucidate the underlying mechanisms of intervention effects.
Primary Outcome
A composite of performance on Verbal fluency words generated, Trail Making Test time, and Digit Symbol Coding number correct derived from principal components analyses
Interventions
- BEHAVIORAL Music Training I
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 268 participants |
| Start Date | 2018-01-29 |
| Est. Completion | 2021-12-30 |
| Phase | NA |
What the finished NCT03528486 record still lists
NCT03528486 is an interventional study that assigns participants to a tested intervention. The registered 268 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (81% lower).
The record links to 0 conditions, and to 1 intervention - of which Music Training I is the first listed.
NCT03528486 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03528486 about?
NCT03528486 is a clinical study titled "Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp". Different cognitive intervention approaches have been developed to attenuate decline (e.g., cognitive engagement, training, or stimulation), but it is not clear which approaches are efficacious. It is also not clear when, along the continuum of normal cognitive aging to mild cognitive impairment (MC...
What is the current status of trial NCT03528486?
This trial is currently completed. It is a NA study. The enrollment target is 268 participants. The study started on 2018-01-29. Estimated completion is 2021-12-30.
What interventions are being tested in trial NCT03528486?
The interventions under investigation include: Music Training I (BEHAVIORAL).
Who is sponsoring clinical trial NCT03528486?
This trial is sponsored by University of South Florida, which has 252 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03528486's enrollment target sits among peer trials
268 392nd of 2000 higher than 1,606 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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