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NCT03494114 · ClinicalTrials.gov registry record · Phase 1
Imaging Activated Macrophages in the Lungs
A Phase 1 study, sponsored by Vanderbilt University Medical Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
NCT03494114: Clinical Trial Phase 1 study, sponsored by Vanderbilt University Medical Center.
NCT03494114 is a Phase 1 study that was terminated before completion, run by Vanderbilt University Medical Center. The registered enrollment target is 13 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03494114, a Phase 1 study, was terminated before completion, sponsored by Vanderbilt University Medical Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
To test whether folate-based positron emission tomography (PET) imaging using 68Ga-EC2115 can differentiate chronic obstructive pulmonary disease (COPD) patients from control subjects and determine whether the PET signal correlates with measurements of inflammation and disease severity.
Primary Outcome
We will compare the PET signal from 68 Ga-EC2115 in the lungs (opposite lung to the one containing a lung nodule) to the number of macrophages and other inflammatory cells obtained by BAL, particularly those expressing folate receptor beta.
Interventions
- DRUG Ga-EC2115
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2018-11-29 |
| Est. Completion | 2021-01-13 |
| Phase | Phase 1 |
Why NCT03494114 stopped before completion
NCT03494114 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 1 intervention - of which Ga-EC2115 is the first listed.
NCT03494114 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03494114 about?
NCT03494114 is a clinical study titled "Imaging Activated Macrophages in the Lungs". To test whether folate-based positron emission tomography (PET) imaging using 68Ga-EC2115 can differentiate chronic obstructive pulmonary disease (COPD) patients from control subjects and determine whether the PET signal correlates with measurements of inflammation and disease severity.
What is the current status of trial NCT03494114?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2018-11-29. Estimated completion is 2021-01-13.
What interventions are being tested in trial NCT03494114?
The interventions under investigation include: Ga-EC2115 (DRUG).
Who is sponsoring clinical trial NCT03494114?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03494114's enrollment target sits among peer trials
13 1847th of 2000 higher than 149 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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