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NCT03492788 · ClinicalTrials.gov registry record · NA
Optimizing CRT With ECGI
A NA study, sponsored by Washington University School of Medicine.
- Terminated
- Registry status
- NA
- Development phase
- 3
- Enrollment target
NCT03492788: Clinical Trial NA study, sponsored by Washington University School of Medicine.
NCT03492788 is a NA study that was terminated before completion, run by Washington University School of Medicine. The registered enrollment target is 3 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03492788, a NA study, was terminated before completion, sponsored by Washington University School of Medicine.
- TERMINATED
- Registry status
- NA
- Development phase
- 3 participants
- Enrollment target
Study Summary
CRT is delivered from two electrodes on opposite sides of the heart \[right (RV) and left ventricle (LV)\] delivering stimulation for more efficient heart beats. There is flexibility in the sequence and temporal staggering of the stimulation from these two electrodes with a different optimum for different patients. However, standard techniques to figure out the optimal stimulation strategy like standard 12-lead surface electrical recording (ECG) or routine ultrasound have failed. The investigators have developed ECG imaging (ECGI) with 250 electrode surface recording combined with CT scan to reconstruct high resolution 4-dimensional panoramic electrical maps of the heart. The study seeks to enroll 56 patients undergoing CRT in a clinical trail to evaluate short and long term impact of using ECGI for optimal programming of CRT.
Primary Outcome
Echocardiographically evaluated % reduction in LV end-systolic volume (LVESV) from baseline is the primary outcome measure. A reduction in the LVESV is a validated surrogate marker of improved HF outcomes including reduced hospitalizations and increased survival.
Interventions
- OTHER ECGI-optimized VV-offset
- OTHER Zero VV-offset
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2017-12-28 |
| Est. Completion | 2018-10-05 |
| Phase | NA |
Why NCT03492788 stopped before completion
NCT03492788 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which ECGI-optimized VV-offset is the first listed.
NCT03492788 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03492788 about?
NCT03492788 is a clinical study titled "Optimizing CRT With ECGI". CRT is delivered from two electrodes on opposite sides of the heart \[right (RV) and left ventricle (LV)\] delivering stimulation for more efficient heart beats. There is flexibility in the sequence and temporal staggering of the stimulation from these two electrodes with a different optimum for dif...
What is the current status of trial NCT03492788?
This trial is currently terminated. It is a NA study. The enrollment target is 3 participants. The study started on 2017-12-28. Estimated completion is 2018-10-05.
What interventions are being tested in trial NCT03492788?
The interventions under investigation include: ECGI-optimized VV-offset (OTHER), Zero VV-offset (OTHER).
Who is sponsoring clinical trial NCT03492788?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03492788's enrollment target sits among peer trials
3 1996th of 2000 higher than 4 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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