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NCT03492021 · ClinicalTrials.gov registry record · NA
Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction
A NA study, sponsored by University of Connecticut.
- Completed
- Registry status
- NA
- Development phase
- 6
- Enrollment target
NCT03492021: Completed NA study, sponsored by University of Connecticut.
NCT03492021 is a NA study that has completed, run by University of Connecticut. The registered enrollment target is 6 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03492021, a NA study, has completed, sponsored by University of Connecticut.
- COMPLETED
- Registry status
- NA
- Development phase
- 6 participants
- Enrollment target
Study Summary
Musculoskeletal injury, particularly injuries requiring surgical repair, induce significant muscle atrophy, resulting in diminished physical function. The protein turnover-associated (diminished protein synthesis, elevated protein breakdown, negative net muscle protein balance) etiology of injury and surgical-induced atrophy are, in part, similar to those observed with muscle wasting induced by hyper-catabolic and inflammatory conditions and prolonged periods of skeletal muscle disuse (e.g., cachexia and joint immobilization). Combining dietary strategies to optimize the anabolic properties of beef as a high quality protein source that provides essential amino acids prior to surgery and throughout post-surgery rehabilitation may attenuate muscle atrophy and accelerate the restoration of muscle function. This project will examine the efficacy of habitual consumption of a beef-based higher protein meal pattern and post-physical rehabilitation beef protein supplementation throughout post-surgical rehabilitation intervention on skeletal muscle function in response to anterior cruciate ligament (ACL) repair in healthy, physically active adults. Stable isotope methodologies, proteomic analysis of muscle protein synthesis, and molecular assessments of skeletal muscle atrophy and remodeling will be assessed to evaluate the effects of increased protein intake, including consumption of a high quality beef-based protein supplement following patient physical therapy sessions on: 1. Skeletal muscle protein fractional synthetic rates during and in recovery from surgery; 2. Inflammatory, proteolytic, and anabolic intramuscular signaling during surgery and their association with skeletal muscle protein synthesis and muscle function; 3. Muscle size and functional recovery; 4. Duration to return to routine exercise, sport, or physical activity.
Primary Outcome
Using stable isotope techniques skeletal muscle protein fractional synthetic rates will be determined
Interventions
- OTHER Diet Intervention_AP-CPT
- OTHER Diet Intervention_PP-PPT
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2018-02-01 |
| Est. Completion | 2022-02-01 |
| Phase | NA |
What the finished NCT03492021 record still lists
NCT03492021 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which Diet Intervention_AP-CPT is the first listed.
NCT03492021 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03492021 about?
NCT03492021 is a clinical study titled "Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction". Musculoskeletal injury, particularly injuries requiring surgical repair, induce significant muscle atrophy, resulting in diminished physical function. The protein turnover-associated (diminished protein synthesis, elevated protein breakdown, negative net muscle protein balance) etiology of injury an...
What is the current status of trial NCT03492021?
This trial is currently completed. It is a NA study. The enrollment target is 6 participants. The study started on 2018-02-01. Estimated completion is 2022-02-01.
What interventions are being tested in trial NCT03492021?
The interventions under investigation include: Diet Intervention_AP-CPT (OTHER), Diet Intervention_PP-PPT (OTHER).
Who is sponsoring clinical trial NCT03492021?
This trial is sponsored by University of Connecticut, which has 107 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03492021's enrollment target sits among peer trials
6 1983rd of 2000 higher than 13 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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