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NCT03484520 · ClinicalTrials.gov registry record · Phase 1
A Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory Acute Myeloid Leukemia
A Phase 1 study, sponsored by AbbVie.
- Terminated
- Registry status
- Phase 1
- Development phase
- 48
- Enrollment target
NCT03484520: Clinical Trial Phase 1 study, sponsored by AbbVie.
NCT03484520 is a Phase 1 study that was terminated before completion, run by AbbVie. The registered enrollment target is 48 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (20% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03484520, a Phase 1 study, was terminated before completion, sponsored by AbbVie.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 48 participants
- Enrollment target
Study Summary
An open-label, dose-escalation study to assess safety, pharmacokinetics and efficacy as well as determine the recommended Phase 2 doses of co-administered therapy of dinaciclib and venetoclax for patients with relapsed or refractory Acute Myeloid Leukemia (R/R AML).
Primary Outcome
Time to maximum plasma concentration (Tmax) of venetoclax.
Interventions
- DRUG Venetoclax
- DRUG Dinaciclib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2018-07-23 |
| Est. Completion | 2022-12-01 |
| Phase | Phase 1 |
Why NCT03484520 stopped before completion
NCT03484520 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (20% lower).
The record links to 0 conditions, and to 2 interventions - of which Venetoclax is the first listed.
NCT03484520 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03484520 about?
NCT03484520 is a clinical study titled "A Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory Acute Myeloid Leukemia". An open-label, dose-escalation study to assess safety, pharmacokinetics and efficacy as well as determine the recommended Phase 2 doses of co-administered therapy of dinaciclib and venetoclax for patients with relapsed or refractory Acute Myeloid Leukemia (R/R AML).
What is the current status of trial NCT03484520?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2018-07-23. Estimated completion is 2022-12-01.
What interventions are being tested in trial NCT03484520?
The interventions under investigation include: Venetoclax (DRUG), Dinaciclib (DRUG).
Who is sponsoring clinical trial NCT03484520?
This trial is sponsored by AbbVie, which has 526 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03484520's enrollment target sits among peer trials
48 1025th of 2000 higher than 948 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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