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NCT03474003 · ClinicalTrials.gov registry record
Development and Validation of a Multidimensional Score to Predict Long-term Kidney Transplant Outcomes
A clinical trial, sponsored by Paris Translational Research Center for Organ Transplantation.
- Completed
- Registry status
- 7,557
- Enrollment target
NCT03474003: Completed study, sponsored by Paris Translational Research Center for Organ Transplantation.
NCT03474003 is a clinical trial that has completed, run by Paris Translational Research Center for Organ Transplantation. The registered enrollment target is 7,557 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03474003 has completed, sponsored by Paris Translational Research Center for Organ Transplantation.
- COMPLETED
- Registry status
- 7,557 participants
- Enrollment target
Study Summary
To further develop personalized medicine in kidney transplantation and improve transplant patient outcomes, attention has been given to define early surrogate endpoints that might aid therapeutic interventions, clinical trials and clinical decision-making. Despite a clear pressing need, no population-scale prognostication system exists that will combine traditional factors and biomarker candidates to represent the complete spectrum of risk predicting parameters. To adequately predict transplant patients' individual risks of allograft loss, this would require a complex integration of data, including: donor data, recipient characteristics, transplant characteristics, allograft precision phenotypes, ethnicity, immunosuppressive regimen monitoring, allograft infections, acute kidney injuries, and recipient immune profiles. This project aims: 1. To develop a generalizable, transportable, mechanistically and data driven composite surrogate end point in kidney transplantation; 2. To validate several risk scores to predict kidney allograft survival and response to treatment of individual patients; Eventually, it will provide an easily accessible tool to calculate individual patients' risk profiles after kidney transplantation, by using datasets from prospective cohorts and post hoc analysis of randomized control trial datasets.
Primary Outcome
Allograft survival probability, calculated from a composite score (based on clinical, histological, immunological, and functional variables) assessed at the time of biopsy.
Interventions
- OTHER No intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,557 participants |
| Start Date | 2002-01 |
| Est. Completion | 2020-04-29 |
What the finished NCT03474003 record still lists
NCT03474003 is an observational study that tracks outcomes without assigning an intervention. Its 7,557 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 1 intervention - of which No intervention is the first listed.
NCT03474003 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03474003 about?
NCT03474003 is a clinical study titled "Development and Validation of a Multidimensional Score to Predict Long-term Kidney Transplant Outcomes". To further develop personalized medicine in kidney transplantation and improve transplant patient outcomes, attention has been given to define early surrogate endpoints that might aid therapeutic interventions, clinical trials and clinical decision-making. Despite a clear pressing need, no populati...
What is the current status of trial NCT03474003?
This trial is currently completed. The enrollment target is 7,557 participants. The study started on 2002-01. Estimated completion is 2020-04-29.
What interventions are being tested in trial NCT03474003?
The interventions under investigation include: No intervention (OTHER).
Who is sponsoring clinical trial NCT03474003?
This trial is sponsored by Paris Translational Research Center for Organ Transplantation, which has 7 total clinical trials registered on ClinicalTrials.gov.
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