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NCT03458819 · ClinicalTrials.gov registry record
EMT in Peritoneal Dialysis Patients
A clinical trial, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 22
- Enrollment target
NCT03458819 is a clinical trial that has completed, run by University of Colorado, Denver. The registered enrollment target is 22 participants.
The verdict
NCT03458819 has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 22 participants
- Enrollment target
Study Summary
Approximately 10-11% of end stage kidney disease patients worldwide utilize peritoneal dialysis (PD) as their method of renal replacement therapy. Over time, the peritoneal membrane often undergoes anatomic and functional changes due to the process of epithelial to mesenchymal transition (EMT). EMT is characterized by increases in pro-inflammatory and pro-angiogenic cytokines. In this process, the mesothelial cells lining the peritoneal membrane are denuded and change their morphology to one more closely resembling fibroblasts. These fibroblasts invade the submesothelial zone of the peritoneal membrane resulting in marked fibrosis, and the pro-angiogenic cytokines cause an increase in neovascularization. Jointly, these processes culminate in impaired function of the peritoneal membrane and often limit the duration of effective PD therapy. In vitro studies in cultured human peritoneal mesothelial cells (HPMCs) and in vivo studies in rodent models of PD have demonstrated that the use of active Vitamin D receptor agonists or statins may attenuate this process of EMT. These are both classes of drugs that are commonly in use by patients on PD. The investigators goal is to determine whether either or both of these drugs might attenuate the process of EMT in patients performing PD.
Interventions
- DIAGNOSTIC_TEST Isolation of peritoneal mesothelial cells
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2018-03-20 |
| Est. Completion | 2019-05-22 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03458819
The ClinicalTrials.gov registry entry for NCT03458819 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Isolation of peritoneal mesothelial cells is the first listed.
NCT03458819 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03458819 about?
NCT03458819 is a clinical study titled "EMT in Peritoneal Dialysis Patients". Approximately 10-11% of end stage kidney disease patients worldwide utilize peritoneal dialysis (PD) as their method of renal replacement therapy. Over time, the peritoneal membrane often undergoes anatomic and functional changes due to the process of epithelial to mesenchymal transition (EMT). EMT ...
What is the current status of trial NCT03458819?
This trial is currently completed. The enrollment target is 22 participants. The study started on 2018-03-20. Estimated completion is 2019-05-22.
What interventions are being tested in trial NCT03458819?
The interventions under investigation include: Isolation of peritoneal mesothelial cells (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03458819?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
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