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NCT03454087 · ClinicalTrials.gov registry record · NA
Study of Early Enteral Dextrose in Sepsis
A NA study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 58
- Enrollment target
NCT03454087: Completed NA study, sponsored by University of Pittsburgh.
NCT03454087 is a NA study that has completed, run by University of Pittsburgh. The registered enrollment target is 58 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03454087, a NA study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 58 participants
- Enrollment target
Study Summary
This study is a prospective single-center randomized double-blinded placebo-controlled clinical trial testing the effects of early enteral dextrose as a therapeutic agent in critically ill patients with sepsis. Primary outcomes are differences in circulating plasma levels of the pro-inflammatory cytokine IL-6 to be tested 24 hours after the start of enteral infusion. Secondary outcomes include differences in circulating incretin hormone levels, differences in other pro-inflammatory cytokines including IL-1β and TNF-α, changes in intestinal microbial composition and function after intervention, glycemic control and variability as assessed by capillary blood glucose measurements and exogenous insulin dosing during the intervention period, and clinical outcomes including intensive care unit (ICU) and hospital stay and in-hospital mortality.
Primary Outcome
Pro-inflammatory cytokine
Interventions
- OTHER Enteral Dextrose Infusion
- OTHER Free Water Infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 58 participants |
| Start Date | 2018-06-04 |
| Est. Completion | 2020-04-01 |
| Phase | NA |
What the finished NCT03454087 record still lists
NCT03454087 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 58 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Enteral Dextrose Infusion is the first listed.
NCT03454087 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03454087 about?
NCT03454087 is a clinical study titled "Study of Early Enteral Dextrose in Sepsis". This study is a prospective single-center randomized double-blinded placebo-controlled clinical trial testing the effects of early enteral dextrose as a therapeutic agent in critically ill patients with sepsis. Primary outcomes are differences in circulating plasma levels of the pro-inflammatory cyt...
What is the current status of trial NCT03454087?
This trial is currently completed. It is a NA study. The enrollment target is 58 participants. The study started on 2018-06-04. Estimated completion is 2020-04-01.
What interventions are being tested in trial NCT03454087?
The interventions under investigation include: Enteral Dextrose Infusion (OTHER), Free Water Infusion (OTHER).
Who is sponsoring clinical trial NCT03454087?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03454087's enrollment target sits among peer trials
58 1256th of 2000 higher than 740 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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