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NCT03449524 · ClinicalTrials.gov registry record · Phase 2
PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)
A Phase 2 study, sponsored by Complexa.
- Terminated
- Registry status
- Phase 2
- Development phase
- 69
- Enrollment target
NCT03449524: Clinical Trial Phase 2 study, sponsored by Complexa.
NCT03449524 is a Phase 2 study that was terminated before completion, run by Complexa. The registered enrollment target is 69 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (48% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03449524, a Phase 2 study, was terminated before completion, sponsored by Complexa.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 69 participants
- Enrollment target
Study Summary
This is a multicenter double-blind, placebo-controlled study to evaluate the safety, efficacy and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to 80 years of age with PAH.
Primary Outcome
• To determine the efficacy of oral doses of CXA-10 on stable background therapy administered for 6 months in subjects with PAH assessed by right ventricular ejection fraction (RVEF) as measured by Cardiac MRI
Interventions
- OTHER Placebo
- DRUG 75mg CXA-10
- DRUG 150mg CXA-10
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2018-08-01 |
| Est. Completion | 2020-08-05 |
| Phase | Phase 2 |
Why NCT03449524 stopped before completion
NCT03449524 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 69 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (48% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT03449524 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03449524 about?
NCT03449524 is a clinical study titled "PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)". This is a multicenter double-blind, placebo-controlled study to evaluate the safety, efficacy and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to 80 years of age with PAH.
What is the current status of trial NCT03449524?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 69 participants. The study started on 2018-08-01. Estimated completion is 2020-08-05.
What interventions are being tested in trial NCT03449524?
The interventions under investigation include: Placebo (OTHER), 75mg CXA-10 (DRUG), 150mg CXA-10 (DRUG).
Who is sponsoring clinical trial NCT03449524?
This trial is sponsored by Complexa, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03449524's enrollment target sits among peer trials
69 965th of 2000 higher than 1,034 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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