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NCT03435250 · ClinicalTrials.gov registry record · Phase 1
Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss
A Phase 1 study, sponsored by Institut de Recherches Internationales Servier.
- Terminated
- Registry status
- Phase 1
- Development phase
- 123
- Enrollment target
NCT03435250: Clinical Trial Phase 1 study, sponsored by Institut de Recherches Internationales Servier.
NCT03435250 is a Phase 1 study that was terminated before completion, run by Institut de Recherches Internationales Servier. The registered enrollment target is 123 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (105% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03435250, a Phase 1 study, was terminated before completion, sponsored by Institut de Recherches Internationales Servier.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 123 participants
- Enrollment target
Study Summary
This study will evaluate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of AG-270 in participants with advanced solid tumors or lymphoma with homozygous MTAP deletion.
Interventions
- DRUG nab-paclitaxel
- DRUG docetaxel
- DRUG AG-270
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 123 participants |
| Start Date | 2018-03-04 |
| Est. Completion | 2023-04-20 |
| Phase | Phase 1 |
Why NCT03435250 stopped before completion
NCT03435250 is an interventional study that assigns participants to a tested intervention. The registered 123 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (105% higher).
The record links to 0 conditions, and to 3 interventions - of which nab-paclitaxel is the first listed.
NCT03435250 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03435250 about?
NCT03435250 is a clinical study titled "Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss". This study will evaluate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of AG-270 in participants with advanced solid tumors or lymphoma with homozygous MTAP deletion.
What is the current status of trial NCT03435250?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 123 participants. The study started on 2018-03-04. Estimated completion is 2023-04-20.
What interventions are being tested in trial NCT03435250?
The interventions under investigation include: nab-paclitaxel (DRUG), docetaxel (DRUG), AG-270 (DRUG).
Who is sponsoring clinical trial NCT03435250?
This trial is sponsored by Institut de Recherches Internationales Servier, which has 27 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03435250's enrollment target sits among peer trials
123 475th of 2000 higher than 1,526 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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