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NCT03417492 · ClinicalTrials.gov registry record · Phase 1
Cerebrovascular Reactivity in American Football Players
A Phase 1 study, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- Phase 1
- Development phase
- 7
- Enrollment target
NCT03417492: Clinical Trial Phase 1 study, sponsored by University of Pennsylvania.
NCT03417492 is a Phase 1 study that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 7 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03417492, a Phase 1 study, was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 7 participants
- Enrollment target
Study Summary
Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after repetitive mild traumatic brain injury (rmTBI) as a biomarker of traumatic cerebrovascular injury (TCVI). We hypothesize that CVR will be decreased in patients with rmTBI and that these decreases will correlate with clinical outcomes. Furthermore, we predict that 5 week administration of a phosphodiesterase 5 (PDE5) inhibitor, sildenafil citrate, will augment CVR in patients with a history rmTBI.
Interventions
- DRUG Sildenafil Citrate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2018-03-01 |
| Est. Completion | 2022-06-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03417492
The ClinicalTrials.gov registry entry for NCT03417492 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 7 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Sildenafil Citrate is the first listed.
NCT03417492 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03417492 about?
NCT03417492 is a clinical study titled "Cerebrovascular Reactivity in American Football Players". Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after repetitive mild traumatic brain injury (rmTBI) as a biomarker of traumatic cerebrovascular injury (TCVI). We hypothesize...
What is the current status of trial NCT03417492?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 7 participants. The study started on 2018-03-01. Estimated completion is 2022-06-30.
What interventions are being tested in trial NCT03417492?
The interventions under investigation include: Sildenafil Citrate (DRUG).
Who is sponsoring clinical trial NCT03417492?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
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