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NCT03413657 · ClinicalTrials.gov registry record · NA
Predicting Fluid Responsiveness Using Transiently Increased Intrathoracic Pressure in Mechanically Ventilated Patients
A NA study, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT03413657: Completed NA study, sponsored by University of California, Davis.
NCT03413657 is a NA study that has completed, run by University of California, Davis. The registered enrollment target is 5 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03413657, a NA study, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
The goal of this study is to identify in patients requiring active fluid resuscitation and mechanical ventilation for circulatory shock, can a controlled increase in intrathoracic pressure (either by positive-end expiratory pressure (PEEP) or tidal volume (TV)) predict responsiveness to additional fluid resuscitation. We hypothesize that a temporary, physiologically-safe increase in positive-end expiratory pressure (PEEP) and/or a temporary increase in tidal volume (from 6 cc/kg predicted body weight (PBW) to 8 cc/kg PBW) in patients requiring invasive mechanical ventilation will predict fluid responsiveness based upon an assessment of the change in pulse pressure and stroke volume variation.
Primary Outcome
Temporary increase in intrathoracic pressure (PEEP or TV) will predict fluid responsiveness using an absolute increase in pulse pressure variation by 3% or more.
Interventions
- PROCEDURE Increase in intrathoracic pressure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2017-12-27 |
| Est. Completion | 2018-09-13 |
| Phase | NA |
What the finished NCT03413657 record still lists
NCT03413657 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Increase in intrathoracic pressure is the first listed.
NCT03413657 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03413657 about?
NCT03413657 is a clinical study titled "Predicting Fluid Responsiveness Using Transiently Increased Intrathoracic Pressure in Mechanically Ventilated Patients". The goal of this study is to identify in patients requiring active fluid resuscitation and mechanical ventilation for circulatory shock, can a controlled increase in intrathoracic pressure (either by positive-end expiratory pressure (PEEP) or tidal volume (TV)) predict responsiveness to additional f...
What is the current status of trial NCT03413657?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2017-12-27. Estimated completion is 2018-09-13.
What interventions are being tested in trial NCT03413657?
The interventions under investigation include: Increase in intrathoracic pressure (PROCEDURE).
Who is sponsoring clinical trial NCT03413657?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03413657's enrollment target sits among peer trials
5 1988th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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