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NCT03401918 · ClinicalTrials.gov registry record · Phase 2
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
A Phase 2 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 2
- Development phase
- 41
- Enrollment target
NCT03401918: Completed Phase 2 study, sponsored by Stanford University.
NCT03401918 is a Phase 2 study that has completed, run by Stanford University. The registered enrollment target is 41 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (69% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03401918, a Phase 2 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 41 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo implantation. Furthermore we would like to assess for women with an abnormal uterine gene expression whether vaginal progesterone medication improves or alters gene expression and for women with an abnormal microbiome whether antibiotic treatment followed by probiotic treatment normalizes the microbiome.
Primary Outcome
The primary outcome will abnormal microbiome results. An abnormal microbiome will be defined as less then 90% lactobacilli on DNA sequencing
Interventions
- DIAGNOSTIC_TEST Uterine ERA and microbiome testing
- DRUG Oral antibiotics and vaginal probiotics
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2017-08-01 |
| Est. Completion | 2021-07-01 |
| Phase | Phase 2 |
What the finished NCT03401918 record still lists
NCT03401918 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (69% lower).
The record links to 0 conditions, and to 2 interventions - of which Uterine ERA and microbiome testing is the first listed.
NCT03401918 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03401918 about?
NCT03401918 is a clinical study titled "Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility". The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo implantation. Furthermore we would like to assess for women with an ab...
What is the current status of trial NCT03401918?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 41 participants. The study started on 2017-08-01. Estimated completion is 2021-07-01.
What interventions are being tested in trial NCT03401918?
The interventions under investigation include: Uterine ERA and microbiome testing (DIAGNOSTIC_TEST), Oral antibiotics and vaginal probiotics (DRUG).
Who is sponsoring clinical trial NCT03401918?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03401918's enrollment target sits among peer trials
41 1352nd of 2000 higher than 639 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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