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NCT03380923 · ClinicalTrials.gov registry record · NA
Precision High-Intensity Training Through Epigenetics (PHITE)
A NA study, sponsored by University of Alabama at Birmingham.
- Completed
- Registry status
- NA
- Development phase
- 239
- Enrollment target
NCT03380923 is a NA study that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 239 participants.
The verdict
NCT03380923, a NA study, has completed, sponsored by University of Alabama at Birmingham.
- COMPLETED
- Registry status
- NA
- Development phase
- 239 participants
- Enrollment target
Study Summary
The PHITE collaborative team, consisting of Tim Broderick, MD (Overall PI), Wright State University (WSU); Marcas Bamman, PhD (Site PI), The University of Alabama at Birmingham (UAB); and Ron Evans, PhD and Joe Ecker, PhD, Salk Institute for Biological Studies, are working with funding from the US Department of Defense (DoD), Office of Naval Research (ONR), to explore the link between physical training and epigenetics. This is a key interest area for the DoD ONR because it provides high-impact optimization of force readiness in warfighters with diverse backgrounds. The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence; a change in phenotype (the set of observable characteristics of an individual resulting from the interaction of its genotype with the environment) without a change in genotype (the genetic constitution of an individual organism) . This in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. New and ongoing research is continuously uncovering the role of epigenetics in a variety of human conditions. This study is designed to assess whether epigenetics is a primary mechanism modulating how individuals adapt to specific exercise training prescriptions designed to produce a warfighter phenotype. The PHITE team is organized around a shared test population of human subjects for which UAB will oversee recruitment, training, testing, and sampling. Healthy but untrained volunteers, both men and women, 18-27 y of age-phenotypical of the US warfighter-will participate in a 12-wk, two-arm, single-blind, randomized, exercise dose-response trial comparing tw
Interventions
- BEHAVIORAL High Intensity
- BEHAVIORAL Moderate Intensity
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 239 participants |
| Start Date | 2017-02-23 |
| Est. Completion | 2021-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03380923
The ClinicalTrials.gov registry entry for NCT03380923 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 239 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which High Intensity is the first listed.
NCT03380923 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03380923 about?
NCT03380923 is a clinical study titled "Precision High-Intensity Training Through Epigenetics (PHITE)". The PHITE collaborative team, consisting of Tim Broderick, MD (Overall PI), Wright State University (WSU); Marcas Bamman, PhD (Site PI), The University of Alabama at Birmingham (UAB); and Ron Evans, PhD and Joe Ecker, PhD, Salk Institute for Biological Studies, are working with funding from the US D...
What is the current status of trial NCT03380923?
This trial is currently completed. It is a NA study. The enrollment target is 239 participants. The study started on 2017-02-23. Estimated completion is 2021-07-31.
What interventions are being tested in trial NCT03380923?
The interventions under investigation include: High Intensity (BEHAVIORAL), Moderate Intensity (BEHAVIORAL).
Who is sponsoring clinical trial NCT03380923?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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