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NCT03378466 · ClinicalTrials.gov registry record · Phase 2
Heparin Anticoagulation in Septic Shock
A Phase 2 study, sponsored by University of Manitoba.
- Terminated
- Registry status
- Phase 2
- Development phase
- 178
- Enrollment target
NCT03378466: Clinical Trial Phase 2 study, sponsored by University of Manitoba.
NCT03378466 is a Phase 2 study that was terminated before completion, run by University of Manitoba. The registered enrollment target is 178 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (34% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03378466, a Phase 2 study, was terminated before completion, sponsored by University of Manitoba.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 178 participants
- Enrollment target
Study Summary
This study is a pragmatic open-label international randomized trial comparing therapeutic dose intravenous unfractionated heparin (UFH) to standard care venous thromboprophylaxis in patients diagnosed with septic shock.
Primary Outcome
The goal of phase II trial is to provide the international Data Safety Monitoring Committee (DSMC) with a sensible estimate to justify continued enrollment in an adaptive (sample size) trial. Vasopressor use, reflecting cardiovascular collapse due to overwhelming systematic inflammation, is a key inclusion criterion for the trial and durable discontinuation of such drugs and meaningful clinical improvement. Vasopressor-free days has been recommended as a preferred clinical outcome in phase II tr
Interventions
- DRUG Unfractionated heparin
- OTHER Venous thromboprophylaxis (VTE)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2018-03-12 |
| Est. Completion | 2021-12-31 |
| Phase | Phase 2 |
Why NCT03378466 stopped before completion
NCT03378466 is an interventional study that assigns participants to a tested intervention. The registered 178 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (34% higher).
The record links to 0 conditions, and to 2 interventions - of which Unfractionated heparin is the first listed.
NCT03378466 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03378466 about?
NCT03378466 is a clinical study titled "Heparin Anticoagulation in Septic Shock". This study is a pragmatic open-label international randomized trial comparing therapeutic dose intravenous unfractionated heparin (UFH) to standard care venous thromboprophylaxis in patients diagnosed with septic shock.
What is the current status of trial NCT03378466?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 178 participants. The study started on 2018-03-12. Estimated completion is 2021-12-31.
What interventions are being tested in trial NCT03378466?
The interventions under investigation include: Unfractionated heparin (DRUG), Venous thromboprophylaxis (VTE) (OTHER).
Who is sponsoring clinical trial NCT03378466?
This trial is sponsored by University of Manitoba, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03378466's enrollment target sits among peer trials
178 391st of 2000 higher than 1,607 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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