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NCT03370991 · ClinicalTrials.gov registry record · NA
Blueberries for Improving Vascular Endothelial Function in Postmenopausal Women With Elevated Blood Pressure
A NA study, sponsored by Colorado State University.
- Completed
- Registry status
- NA
- Development phase
- 43
- Enrollment target
NCT03370991 is a NA study that has completed, run by Colorado State University. The registered enrollment target is 43 participants.
The verdict
NCT03370991, a NA study, has completed, sponsored by Colorado State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 43 participants
- Enrollment target
Study Summary
Postmenopausal women are at an increased risk of developing cardiovascular disease (CVD) largely due to accelerated aging-related modifications to vascular health following menopause. The vascular endothelium is responsible for producing chemicals that are essential for proper vasodilation and blood flow and therefore is involved in maintaining normal blood pressure. A major modification that occurs during aging and is accelerated during menopause is termed vascular endothelial dysfunction which is characterized by impaired endothelium-dependent dilation. This can lead to increased blood pressure, atherosclerosis, and increased risk of CVD and death. Nitric oxide (NO) is a chemical produced by the endothelium and is essential for normal endothelial function and cardiovascular health. Vascular endothelial dysfunction is primarily caused by reduced NO bioavailability secondary to excessive oxidative stress. Approximately 3/4 of postmenopausal women have elevated blood pressure or hypertension which further worsens endothelial function and increases CVD risk through increased oxidative stress and inflammation. Blueberries are rich in phytochemicals including anthocyanins, phenolic acids, and pterostilbene. These phytochemicals and their metabolites are known to attenuate oxidative stress and inflammation. The overall goal of the current study is to assess the efficacy of blueberries to improve vascular endothelial dysfunction in this high-risk population and to gain insight into underlying mechanisms. 58 postmenopausal women with elevated blood pressure and stage 1-HTN will be asked to consume 22 grams freeze-dried blueberry powder or placebo powder per day for 12 weeks. Vascular endothelial function will be assessed at baseline and 12 weeks. Measurements indicative of vascular nitric oxide production, oxidative stress, inflammation, cardiometabolic health, cognitive function, and blueberry phytochemical metabolism will be measured at baseline and 12 weeks. Blood press
Interventions
- DIETARY_SUPPLEMENT Blueberry Powder
- DIETARY_SUPPLEMENT Placebo Powder
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 43 participants |
| Start Date | 2017-12-02 |
| Est. Completion | 2021-09-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03370991
The ClinicalTrials.gov registry entry for NCT03370991 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 43 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Colorado State University, which has 94 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Blueberry Powder is the first listed.
NCT03370991 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03370991 about?
NCT03370991 is a clinical study titled "Blueberries for Improving Vascular Endothelial Function in Postmenopausal Women With Elevated Blood Pressure". Postmenopausal women are at an increased risk of developing cardiovascular disease (CVD) largely due to accelerated aging-related modifications to vascular health following menopause. The vascular endothelium is responsible for producing chemicals that are essential for proper vasodilation and blood...
What is the current status of trial NCT03370991?
This trial is currently completed. It is a NA study. The enrollment target is 43 participants. The study started on 2017-12-02. Estimated completion is 2021-09-30.
What interventions are being tested in trial NCT03370991?
The interventions under investigation include: Blueberry Powder (DIETARY_SUPPLEMENT), Placebo Powder (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03370991?
This trial is sponsored by Colorado State University, which has 94 total clinical trials registered on ClinicalTrials.gov.
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