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NCT03344250 · ClinicalTrials.gov registry record · Phase 1
Phase I EGFR BATs in Newly Diagnosed Glioblastoma
A Phase 1 study, sponsored by University of Virginia.
- Completed
- Registry status
- Phase 1
- Development phase
- 16
- Enrollment target
NCT03344250: Completed Phase 1 study, sponsored by University of Virginia.
NCT03344250 is a Phase 1 study that has completed, run by University of Virginia. The registered enrollment target is 16 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03344250, a Phase 1 study, has completed, sponsored by University of Virginia.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
This is a phase I trial using EGFR Bi-armed Activated T-cells (BATs) in combination with standard of care temozolomide (TMZ) and radiation (RT) in patients with glioblastoma (GBM). The purpose of the study is to determine a safe dose of EGFR BATs when given with standard of care therapy.
Primary Outcome
Maximum tolerated dose will be based on number of dose limiting toxicities at each dose level
Interventions
- DRUG EGFR BATs with TMZ following SOC RT/TMZ
- DRUG Weekly EGFR BATs following SOC RT/TMZ
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2018-03-01 |
| Est. Completion | 2023-05-08 |
| Phase | Phase 1 |
What the finished NCT03344250 record still lists
NCT03344250 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower).
The record links to 0 conditions, and to 2 interventions - of which EGFR BATs with TMZ following SOC RT/TMZ is the first listed.
NCT03344250 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03344250 about?
NCT03344250 is a clinical study titled "Phase I EGFR BATs in Newly Diagnosed Glioblastoma". This is a phase I trial using EGFR Bi-armed Activated T-cells (BATs) in combination with standard of care temozolomide (TMZ) and radiation (RT) in patients with glioblastoma (GBM). The purpose of the study is to determine a safe dose of EGFR BATs when given with standard of care therapy.
What is the current status of trial NCT03344250?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2018-03-01. Estimated completion is 2023-05-08.
What interventions are being tested in trial NCT03344250?
The interventions under investigation include: EGFR BATs with TMZ following SOC RT/TMZ (DRUG), Weekly EGFR BATs following SOC RT/TMZ (DRUG).
Who is sponsoring clinical trial NCT03344250?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03344250's enrollment target sits among peer trials
16 1786th of 2000 higher than 203 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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