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NCT03337113 · ClinicalTrials.gov registry record · Phase 2
Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers
A Phase 2 study, sponsored by Kent State University.
- Completed
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
NCT03337113 is a Phase 2 study that has completed, run by Kent State University. The registered enrollment target is 50 participants.
The verdict
NCT03337113, a Phase 2 study, has completed, sponsored by Kent State University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
Study Summary
Smoking remains the leading cause of preventable death in the United States, and current first-line treatments leave the majority of tobacco dependent individuals unable to quit. The inability to quit despite motivation to do so, is thought to result in part, from self-control failure. Working memory (WM) deficits contribute to imbalanced self-control and allow automatic impulses to drive behavior. Thus, WM plays a critical role in addictive behavior, and is particularly relevant to smoking. Indeed, a strong link between WM and smoking has been established in the literature; most notably, degree of WM impairment and deficits in activation in associated brain regions predict time to relapse, and WM moderates the relationship between craving and relapse. Given these insights, researchers have been examining interventions that may target WM including WM training (WMT) and repetitive Transcranial Magnetic Stimulation (rTMS). WMT involves taxing this executive function repeatedly over time and has shown positive preliminary results in improving measures of self-control and reducing consumption of addictive substances. Similarly, rTMS, a non-invasive brain stimulation procedure that stimulates neuronal tissues and increases cortical excitability, has been shown to increase WM capacity and reduce craving and consumption of several addictive substances including nicotine. While these interventions have demonstrated initial promise in affecting addictive behaviors, the magnitude and durability of their effects may be limited. Recently, researchers have posited - but not yet empirically tested - that WMT administered in combination with rTMS may result in an additive or supra-additive effect in treating addictive processes. This is highly significant; the clinical utility of rTMS over current first line treatments may be limited if factors with potential to enhance its effectiveness are not examined. Given these recent advances in the literature, the primary objective of the
Interventions
- DEVICE repetitive Transcranial Magnetic Stimulation
- OTHER Working Memory Training
- OTHER Sham Working Memory Training
- DEVICE Sham repetitive Transcranial Magnetic Stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2018-03-05 |
| Est. Completion | 2021-01-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03337113
The ClinicalTrials.gov registry entry for NCT03337113 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kent State University, which has 19 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which repetitive Transcranial Magnetic Stimulation is the first listed.
NCT03337113 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03337113 about?
NCT03337113 is a clinical study titled "Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers". Smoking remains the leading cause of preventable death in the United States, and current first-line treatments leave the majority of tobacco dependent individuals unable to quit. The inability to quit despite motivation to do so, is thought to result in part, from self-control failure. Working memor...
What is the current status of trial NCT03337113?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2018-03-05. Estimated completion is 2021-01-31.
What interventions are being tested in trial NCT03337113?
The interventions under investigation include: repetitive Transcranial Magnetic Stimulation (DEVICE), Working Memory Training (OTHER), Sham Working Memory Training (OTHER), Sham repetitive Transcranial Magnetic Stimulation (DEVICE).
Who is sponsoring clinical trial NCT03337113?
This trial is sponsored by Kent State University, which has 19 total clinical trials registered on ClinicalTrials.gov.
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