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NCT03323801 · ClinicalTrials.gov registry record · Phase 2
RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia
A Phase 2 study, sponsored by University of Washington.
- Completed
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
NCT03323801: Completed Phase 2 study, sponsored by University of Washington.
NCT03323801 is a Phase 2 study that has completed, run by University of Washington. The registered enrollment target is 10 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03323801, a Phase 2 study, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
Study Summary
Men with infertility and normal hormone levels have few options for fertility treatment. Previous research suggests that men with infertility may have low levels of the active form of Vitamin A, called retinoic acid, in their testes. In a pilot study of 20 men with low numbers of sperm (\<10 million motile sperm), roughly half the men showed improvement in sperm production. Thus, we want to see if retinoic acid administration to men with azoospermia (no sperm present) can initiate sperm production.
Primary Outcome
Number of participants with undetectable or detectable sperm in their ejaculates.
Interventions
- DRUG 13-cis retinoic acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2017-07-25 |
| Est. Completion | 2019-05-31 |
| Phase | Phase 2 |
What the finished NCT03323801 record still lists
NCT03323801 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which 13-cis retinoic acid is the first listed.
NCT03323801 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03323801 about?
NCT03323801 is a clinical study titled "RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia". Men with infertility and normal hormone levels have few options for fertility treatment. Previous research suggests that men with infertility may have low levels of the active form of Vitamin A, called retinoic acid, in their testes. In a pilot study of 20 men with low numbers of sperm (\<10 million...
What is the current status of trial NCT03323801?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2017-07-25. Estimated completion is 2019-05-31.
What interventions are being tested in trial NCT03323801?
The interventions under investigation include: 13-cis retinoic acid (DRUG).
Who is sponsoring clinical trial NCT03323801?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03323801's enrollment target sits among peer trials
10 1968th of 2000 higher than 12 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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