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NCT03318445 · ClinicalTrials.gov registry record · Phase 1
Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair
A Phase 1 study, sponsored by Pamela Munster.
- Completed
- Registry status
- Phase 1
- Development phase
- 22
- Enrollment target
NCT03318445: Completed Phase 1 study, sponsored by Pamela Munster.
NCT03318445 is a Phase 1 study that has completed, run by Pamela Munster. The registered enrollment target is 22 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (63% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03318445, a Phase 1 study, has completed, sponsored by Pamela Munster.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 22 participants
- Enrollment target
Study Summary
This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.
Primary Outcome
ORR is defined as the proportion of patients with either confirmed complete or partial response (as per RECIST version 1.1) as best overall response over the total population.
Interventions
- DRUG Irinotecan
- DRUG Rucaparib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2018-01-12 |
| Est. Completion | 2021-03-01 |
| Phase | Phase 1 |
What the finished NCT03318445 record still lists
NCT03318445 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (63% lower).
The record links to 0 conditions, and to 2 interventions - of which Irinotecan is the first listed.
NCT03318445 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03318445 about?
NCT03318445 is a clinical study titled "Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair". This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.
What is the current status of trial NCT03318445?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 22 participants. The study started on 2018-01-12. Estimated completion is 2021-03-01.
What interventions are being tested in trial NCT03318445?
The interventions under investigation include: Irinotecan (DRUG), Rucaparib (DRUG).
Who is sponsoring clinical trial NCT03318445?
This trial is sponsored by Pamela Munster, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03318445's enrollment target sits among peer trials
22 1601st of 2000 higher than 386 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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