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NCT03309696 · ClinicalTrials.gov registry record · NA
Regulating Homeostatic Plasticity and the Physiological Response to rTMS
A NA study, sponsored by University of Arkansas.
- Terminated
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT03309696 is a NA study that was terminated before completion, run by University of Arkansas. The registered enrollment target is 10 participants.
The verdict
NCT03309696, a NA study, was terminated before completion, sponsored by University of Arkansas.
- TERMINATED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording. Currently, the application of non-invasive neuromodulation is rarely guided by detailed knowledge of how neural activity is altered in the brain circuits that are targeted for intervention. This gap in knowledge is problematic for interpreting response variability, which is common. To address this gap, the current proposal aims to combine two forms of neuromodulation sequentially, transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), to regulate homeostatic plasticity prior to rTMS delivery at different frequencies of rTMS. Homeostatic plasticity, the initial activation state of a targeted circuit, is a key determinant of whether rTMS induces long term potentiation (LTP) or long term depression (LTD) Yet, homeostatic plasticity is rarely measured or controlled in rTMS studies. We aim to control homeostatic plasticity by preconditioning the targeted circuits with tDCS prior to rTMS delivery. The protocol included an exploratory aim to examine physiological changes in patients with tinnitus but this aim was not part of the pilot physiological investigation and it could not be completed due to funding limitations.
Interventions
- DEVICE sham tDCS and sham rTMS
- DEVICE sham tDCS and active rTMS
- DEVICE active tDCS and active rTMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2017-11-16 |
| Est. Completion | 2019-10-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03309696
The ClinicalTrials.gov registry entry for NCT03309696 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Arkansas, which has 318 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which sham tDCS and sham rTMS is the first listed.
NCT03309696 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03309696 about?
NCT03309696 is a clinical study titled "Regulating Homeostatic Plasticity and the Physiological Response to rTMS". This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording. Currently, the application of non-invasive neuromodulation is rarely guided by deta...
What is the current status of trial NCT03309696?
This trial is currently terminated. It is a NA study. The enrollment target is 10 participants. The study started on 2017-11-16. Estimated completion is 2019-10-01.
What interventions are being tested in trial NCT03309696?
The interventions under investigation include: sham tDCS and sham rTMS (DEVICE), sham tDCS and active rTMS (DEVICE), active tDCS and active rTMS (DEVICE).
Who is sponsoring clinical trial NCT03309696?
This trial is sponsored by University of Arkansas, which has 318 total clinical trials registered on ClinicalTrials.gov.
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