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NCT03293004 · ClinicalTrials.gov registry record · NA
Collagen Vitamin C Dose Response Performance
A NA study, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 23
- Enrollment target
NCT03293004: Completed NA study, sponsored by University of California, Davis.
NCT03293004 is a NA study that has completed, run by University of California, Davis. The registered enrollment target is 23 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03293004, a NA study, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 23 participants
- Enrollment target
Study Summary
Previous work has shown that gelatin supplementation could increase collagen synthesis in humans. In this study subjects consume placebo, 5 or 15 g of gelatin with a standard amount of vitamin C (48 mg) 1 hour before 6 minutes of jump rope exercise. The feeding and exercise intervention was repeated every 6 hours while the subjects were awake for three days and the amount of the amino terminal procollagen I peptide (PINP) was determined; a marker of collagen synthesis, in the blood. Consistent with the hypothesis that gelatin increases collagen synthesis in humans; the amount of PINP in the 15 g gelatin group was significantly higher than either the placebo or the 5 g groups. These data conclusively demonstrate that gelatin supplementation can increase exercise-induced collagen synthesis in humans. Hydrolyzed collagen has a similar amino acid profile, in particular with high concentrations of glycine, proline, hydroxyproline, and arginine. Thus the current study aims to precisely map out the dose response relationship of hydrolyzed collagen and vitamin C on PINP and to determine the optimal dose to achieve maximal increased in PINP levels.
Primary Outcome
To determine optimal dose of supplemental hydrolyzed collagen and vitamin C required to maximally elevate PINP levels (a marker of collagen synthesis) in healthy athletes.
Interventions
- DIETARY_SUPPLEMENT Vitamin C
- DIETARY_SUPPLEMENT Gummy Placebo
- DIETARY_SUPPLEMENT Hydrolyzed collagen
- DIETARY_SUPPLEMENT Optimized Hydrolyzed Collagen and Vitamin C
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2017-09-13 |
| Est. Completion | 2018-05-24 |
| Phase | NA |
What the finished NCT03293004 record still lists
NCT03293004 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 4 interventions - of which Vitamin C is the first listed.
NCT03293004 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03293004 about?
NCT03293004 is a clinical study titled "Collagen Vitamin C Dose Response Performance". Previous work has shown that gelatin supplementation could increase collagen synthesis in humans. In this study subjects consume placebo, 5 or 15 g of gelatin with a standard amount of vitamin C (48 mg) 1 hour before 6 minutes of jump rope exercise. The feeding and exercise intervention was repeated...
What is the current status of trial NCT03293004?
This trial is currently completed. It is a NA study. The enrollment target is 23 participants. The study started on 2017-09-13. Estimated completion is 2018-05-24.
What interventions are being tested in trial NCT03293004?
The interventions under investigation include: Vitamin C (DIETARY_SUPPLEMENT), Gummy Placebo (DIETARY_SUPPLEMENT), Hydrolyzed collagen (DIETARY_SUPPLEMENT), Optimized Hydrolyzed Collagen and Vitamin C (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03293004?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03293004's enrollment target sits among peer trials
23 1755th of 2000 higher than 245 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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