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NCT03288311 · ClinicalTrials.gov registry record · NA
Protocolized Post-Extubation Respiratory Support Study
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 751
- Enrollment target
NCT03288311: Completed NA study, sponsored by Vanderbilt University Medical Center.
NCT03288311 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 751 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (47% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03288311, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 751 participants
- Enrollment target
Study Summary
Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their first extubation. Reintubation is associated with increased rates of nosocomial infection and is an independent predictor of mortality. Non-invasive ventilation and high flow nasal cannula are the only therapies that have been shown to reduce the rate of reintubation. Recent clinical trials suggest that all patients might benefit from some form of post-extubation respiratory support, but use of these therapies in usual care remains low. PROPER is a cluster-randomized, multiple-crossover trial comparing a respiratory therapist driven protocol to provide post-extubation respiratory support to all patients, compared to usual care. The trial will enroll patients undergoing extubation in the Medical ICU at Vanderbilt from October 2017 until March 2019. The primary outcome will be reintubation within 96 hours.
Primary Outcome
Any placement of an endotracheal tube for any indication within 96 hours of extubation, censored at the first of hospital discharge or 96 hours after extubation
Interventions
- OTHER Usual Care
- OTHER Protocolized post-extubation respiratory support
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 751 participants |
| Start Date | 2017-10-01 |
| Est. Completion | 2019-04-28 |
| Phase | NA |
What the finished NCT03288311 record still lists
NCT03288311 is an interventional study that assigns participants to a tested intervention. The registered 751 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (47% lower).
The record links to 0 conditions, and to 2 interventions - of which Usual Care is the first listed.
NCT03288311 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03288311 about?
NCT03288311 is a clinical study titled "Protocolized Post-Extubation Respiratory Support Study". Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their first extubation. Reintubation is associated with increased rates of nosocomial infection and is an in...
What is the current status of trial NCT03288311?
This trial is currently completed. It is a NA study. The enrollment target is 751 participants. The study started on 2017-10-01. Estimated completion is 2019-04-28.
What interventions are being tested in trial NCT03288311?
The interventions under investigation include: Usual Care (OTHER), Protocolized post-extubation respiratory support (OTHER).
Who is sponsoring clinical trial NCT03288311?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03288311's enrollment target sits among peer trials
751 145th of 2000 higher than 1,856 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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