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NCT03275402 · ClinicalTrials.gov registry record · Phase 2
131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases
A Phase 2 study, sponsored by Y-mAbs Therapeutics.
- Terminated
- Registry status
- Phase 2
- Development phase
- 52
- Enrollment target
NCT03275402: Clinical Trial Phase 2 study, sponsored by Y-mAbs Therapeutics.
NCT03275402 is a Phase 2 study that was terminated before completion, run by Y-mAbs Therapeutics. The registered enrollment target is 52 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (61% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03275402, a Phase 2 study, was terminated before completion, sponsored by Y-mAbs Therapeutics.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 52 participants
- Enrollment target
Study Summary
Children with a neuroblastoma diagnose and central nervous system (CNS)/leptomeningeal metastases will be given up to 2 rounds of intracerebroventricular treatment with a radiolabelled monoclonal antibody, 131I-omburtamab to evaluate efficacy and safety
Primary Outcome
Overall survival rate at 3 years after the first treatment dose of 131I-omburtamab estimated by the Kaplan-Meier method.
Interventions
- BIOLOGICAL 131I-omburtamab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2018-12-11 |
| Est. Completion | 2023-06-02 |
| Phase | Phase 2 |
Why NCT03275402 stopped before completion
NCT03275402 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (61% lower).
The record links to 0 conditions, and to 1 intervention - of which 131I-omburtamab is the first listed.
NCT03275402 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03275402 about?
NCT03275402 is a clinical study titled "131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases". Children with a neuroblastoma diagnose and central nervous system (CNS)/leptomeningeal metastases will be given up to 2 rounds of intracerebroventricular treatment with a radiolabelled monoclonal antibody, 131I-omburtamab to evaluate efficacy and safety
What is the current status of trial NCT03275402?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 52 participants. The study started on 2018-12-11. Estimated completion is 2023-06-02.
What interventions are being tested in trial NCT03275402?
The interventions under investigation include: 131I-omburtamab (BIOLOGICAL).
Who is sponsoring clinical trial NCT03275402?
This trial is sponsored by Y-mAbs Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03275402's enrollment target sits among peer trials
52 1181st of 2000 higher than 811 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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