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NCT03270709 · ClinicalTrials.gov registry record · Phase 1
Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV
A Phase 1 study, sponsored by Emory University.
- Terminated
- Registry status
- Phase 1
- Development phase
- 7
- Enrollment target
NCT03270709: Clinical Trial Phase 1 study, sponsored by Emory University.
NCT03270709 is a Phase 1 study that was terminated before completion, run by Emory University. The registered enrollment target is 7 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03270709, a Phase 1 study, was terminated before completion, sponsored by Emory University.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 7 participants
- Enrollment target
Study Summary
Supplementation with vitamin D improves HIV+ macrophages phagocytosis in vitro. There is evidence to suggest that administering vitamin D can in fact improve immune function in individuals. The study will evaluate the impact of high dose vitamin D in HIV+ smokers' and HIV- smokers' in vivo. The primary goal is to improve innate immune host response to infection in patients already at high risk by virtue of HIV and smoking status.
Primary Outcome
A phagocytic index will be determined by challenging AM isolated from bronchoalveolar lavage (BAL) to Staph. Aureus in vitro.
Interventions
- DRUG Vitamin D3 450,000 IU orally
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2018-04-11 |
| Est. Completion | 2018-10-15 |
| Phase | Phase 1 |
Why NCT03270709 stopped before completion
NCT03270709 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 1 intervention - of which Vitamin D3 450,000 IU orally is the first listed.
NCT03270709 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03270709 about?
NCT03270709 is a clinical study titled "Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV". Supplementation with vitamin D improves HIV+ macrophages phagocytosis in vitro. There is evidence to suggest that administering vitamin D can in fact improve immune function in individuals. The study will evaluate the impact of high dose vitamin D in HIV+ smokers' and HIV- smokers' in vivo. The prim...
What is the current status of trial NCT03270709?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 7 participants. The study started on 2018-04-11. Estimated completion is 2018-10-15.
What interventions are being tested in trial NCT03270709?
The interventions under investigation include: Vitamin D3 450,000 IU orally (DRUG).
Who is sponsoring clinical trial NCT03270709?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03270709's enrollment target sits among peer trials
7 1972nd of 2000 higher than 27 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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