Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03262233 · ClinicalTrials.gov registry record · Phase 4
Stress Neuroadaptation in Tobacco Dependence
A Phase 4 study, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- Phase 4
- Development phase
- 226
- Enrollment target
NCT03262233: Completed Phase 4 study, sponsored by University of Wisconsin, Madison.
NCT03262233 is a Phase 4 study that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 226 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (56% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03262233, a Phase 4 study, has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 226 participants
- Enrollment target
Study Summary
The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers during a smoking cessation attempt.
Primary Outcome
The average of unpredictable startle potentiation and predictable startle potentiation during the first administration of the NPU stressor task.
Interventions
- OTHER placebo
- COMBINATION_PRODUCT nicotine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 226 participants |
| Start Date | 2015-04-01 |
| Est. Completion | 2018-02-20 |
| Phase | Phase 4 |
What the finished NCT03262233 record still lists
NCT03262233 is an interventional study that assigns participants to a tested intervention. The registered 226 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (56% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT03262233 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03262233 about?
NCT03262233 is a clinical study titled "Stress Neuroadaptation in Tobacco Dependence". The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers during a smoking cessation attempt.
What is the current status of trial NCT03262233?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 226 participants. The study started on 2015-04-01. Estimated completion is 2018-02-20.
What interventions are being tested in trial NCT03262233?
The interventions under investigation include: placebo (OTHER), nicotine (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT03262233?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03262233's enrollment target sits among peer trials
226 376th of 2000 higher than 1,622 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04419272 · 226 participants · Phase 4
Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
- NCT05449002 · 226 participants · NA
Digital Single Session Intervention for Youth Mental Health
- NCT05488054 · 226 participants · NA
Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
- NCT05924477 · 226 participants · NA
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI