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NCT03248882 · ClinicalTrials.gov registry record · Phase 2
Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)
A Phase 2 study, sponsored by Pfizer.
- Completed
- Registry status
- Phase 2
- Development phase
- 305
- Enrollment target
NCT03248882: Completed Phase 2 study, sponsored by Pfizer.
NCT03248882 is a Phase 2 study that has completed, run by Pfizer. The registered enrollment target is 305 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (129% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03248882, a Phase 2 study, has completed, sponsored by Pfizer.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 305 participants
- Enrollment target
Study Summary
Phase 2a, dose-ranging Study with PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)
Primary Outcome
MRI-PDFF utilized a gradient echo sequence with low flip angle (FA) to minimize T1 bias, corrected T2\* decay (due to iron overload) via modeling of the fat signal as a superposition of multiple frequency components from 5 different lipid types, and was applied in each of the 9 Couinaud segments. This technique improved fat quantification accuracy for the entire liver permitting quantification of small differences/changes following pharmacological intervention.
Interventions
- DRUG Placebo
- DRUG PF-05221304
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 305 participants |
| Start Date | 2017-08-22 |
| Est. Completion | 2019-03-27 |
| Phase | Phase 2 |
What the finished NCT03248882 record still lists
NCT03248882 is an interventional study that assigns participants to a tested intervention. The registered 305 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (129% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03248882 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03248882 about?
NCT03248882 is a clinical study titled "Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)". Phase 2a, dose-ranging Study with PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)
What is the current status of trial NCT03248882?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 305 participants. The study started on 2017-08-22. Estimated completion is 2019-03-27.
What interventions are being tested in trial NCT03248882?
The interventions under investigation include: Placebo (DRUG), PF-05221304 (DRUG).
Who is sponsoring clinical trial NCT03248882?
This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03248882's enrollment target sits among peer trials
305 166th of 2000 higher than 1,835 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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