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NCT03234751 · ClinicalTrials.gov registry record · Phase 1
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
A Phase 1 study, sponsored by AdventHealth Translational Research Institute.
- Completed
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
NCT03234751: Completed Phase 1 study, sponsored by AdventHealth Translational Research Institute.
NCT03234751 is a Phase 1 study that has completed, run by AdventHealth Translational Research Institute. The registered enrollment target is 6 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03234751, a Phase 1 study, has completed, sponsored by AdventHealth Translational Research Institute.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
Study Summary
The purpose of the study is to compare the effects of nesiritide to placebo administered by a continuous IV infusion over 48 hours for the treatment of insulin resistance in healthy, obese, insulin resistant individuals.
Primary Outcome
Average changes in glucose disposal rates (GDR) and endogenous glucose production (EGP) from baseline corrected for body weight at steady state of the clamp during the high- and low-dose portions.
Interventions
- DRUG Placebo
- DRUG Hyperinsulinemic euglycemic clamp
- DRUG Continous IV infusion of Nesiritide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2017-07-13 |
| Est. Completion | 2020-02-19 |
| Phase | Phase 1 |
What the finished NCT03234751 record still lists
NCT03234751 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT03234751 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03234751 about?
NCT03234751 is a clinical study titled "Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects". The purpose of the study is to compare the effects of nesiritide to placebo administered by a continuous IV infusion over 48 hours for the treatment of insulin resistance in healthy, obese, insulin resistant individuals.
What is the current status of trial NCT03234751?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2017-07-13. Estimated completion is 2020-02-19.
What interventions are being tested in trial NCT03234751?
The interventions under investigation include: Placebo (DRUG), Hyperinsulinemic euglycemic clamp (DRUG), Continous IV infusion of Nesiritide (DRUG).
Who is sponsoring clinical trial NCT03234751?
This trial is sponsored by AdventHealth Translational Research Institute, which has 54 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03234751's enrollment target sits among peer trials
6 1974th of 2000 higher than 12 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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