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NCT03229551 · ClinicalTrials.gov registry record · Phase 2
Xylitol for Chronic Sinusitis
A Phase 2 study, sponsored by Ochsner Health System.
- Completed
- Registry status
- Phase 2
- Development phase
- 1
- Enrollment target
NCT03229551: Completed Phase 2 study, sponsored by Ochsner Health System.
NCT03229551 is a Phase 2 study that has completed, run by Ochsner Health System. The registered enrollment target is 1 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03229551, a Phase 2 study, has completed, sponsored by Ochsner Health System.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 1 participants
- Enrollment target
Study Summary
The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical steroid/antibiotics combination in the effort to disrupt biofilms and improve disease control. The effectiveness of topical surfactants is a research gap in treating CRS but has promising correlates in other medical fields. Specifically, the investigators will be studying the effect of topical xylitol therapy on biofilm production with the use of PCR bacterial sequencing before and after medical intervention.
Primary Outcome
Bacterial DNA sequencing obtained via endoscopic swab will be performed pre-treatment to analyse the presence of biofims in the diseased sinus. This assay will be repeated from the same sinus post-treatment with 5% Xylitol (wt/vol) to evaluate if medical intervention decreases biofilm production in the diseased sinus.
Interventions
- DRUG Saline
- DRUG Xylitol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2018-03-01 |
| Est. Completion | 2018-07-16 |
| Phase | Phase 2 |
What the finished NCT03229551 record still lists
NCT03229551 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Saline is the first listed.
NCT03229551 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03229551 about?
NCT03229551 is a clinical study titled "Xylitol for Chronic Sinusitis". The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical steroid/antibiotics combination in the effort to disrupt biofilms and improve disease con...
What is the current status of trial NCT03229551?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 1 participants. The study started on 2018-03-01. Estimated completion is 2018-07-16.
What interventions are being tested in trial NCT03229551?
The interventions under investigation include: Saline (DRUG), Xylitol (DRUG).
Who is sponsoring clinical trial NCT03229551?
This trial is sponsored by Ochsner Health System, which has 29 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03229551's enrollment target sits among peer trials
1 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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