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NCT03194464 · ClinicalTrials.gov registry record · NA
Fatiguing Arm Exercise Following Stroke
A NA study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT03194464: Completed NA study, sponsored by VA Office of Research and Development.
NCT03194464 is a NA study that has completed, run by VA Office of Research and Development. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03194464, a NA study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke. In previous work the investigators found that non-paretic hand exercise to task-failure increased excitability of the motor cortex in the more involved hemisphere and produced behavioral improvements in the unexercised paretic hand. Importantly, the magnitude of increased brain excitability is greater than what has been observed following brain stimulation with either repetitive transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) and lasts longer. This approach could be implemented in the clinical setting and could be accessible to a greater number of people than brain stimulation. The investigators' goals in the current study are to: repeat previous findings in a different group of participants and investigate the neural mechanisms that produce brain and behavioral facilitation in order to inform development of this approach for clinical implementation.
Primary Outcome
SICI is a neurophysiologic measure of intra-cortical inhibition, obtained using transcranial magnetic stimulation (TMS) measured here in the ipsilesional hemisphere (IH) at each point to determine how it is modulated in response to task-failure. SICI is quantified as a ratio where values \<1 reflect inhibition and \>1 disinhibition or relative excitation. In health, SICI is \~0.5. Thus if SICI = 0.8, while \<1 it would indicate less inhibition than expected in health. Transient change in SICI fr
Interventions
- OTHER submaximal exercise (grip)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2016-02-01 |
| Est. Completion | 2018-05-21 |
| Phase | NA |
What the finished NCT03194464 record still lists
NCT03194464 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which submaximal exercise (grip) is the first listed.
NCT03194464 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03194464 about?
NCT03194464 is a clinical study titled "Fatiguing Arm Exercise Following Stroke". This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke. In previous work the investigators found that non-paretic hand exercise to task-failure increased excitability o...
What is the current status of trial NCT03194464?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2016-02-01. Estimated completion is 2018-05-21.
What interventions are being tested in trial NCT03194464?
The interventions under investigation include: submaximal exercise (grip) (OTHER).
Who is sponsoring clinical trial NCT03194464?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03194464's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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