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NCT03190785 · ClinicalTrials.gov registry record · NA
Benzoates - an Obesogenic Endocrine Disrupting Chemical
A NA study, sponsored by East Carolina University.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT03190785 is a NA study that has completed, run by East Carolina University. The registered enrollment target is 20 participants.
The verdict
NCT03190785, a NA study, has completed, sponsored by East Carolina University.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The benzoic acid derivatives sodium and potassium benzoate are preservatives that are commonly added to food and beverages to inhibit microbial growth and prevent spoilage. In the US the major source of benzoate intake is beverages. Studies have shown that piglets or chicks fed low levels of benzoic acid have greater feed efficiency and gain more weight than control fed animals. It has also been shown that benzoic acid inhibits the release of a key metabolic hormone, leptin, from isolated adipocytes (fat cells). Inadequate leptin levels result in increased appetite, decreased metabolic rate, weight gain, insulin resistance and increased diabetes risk. The primary aim of the proposed research is to directly determine if benzoate consumption in human volunteers results in lower levels of leptin, decreased metabolic rate and increased insulin resistance. If so this would implicate benzoic acid as an obesogen and would help inform more effective approaches to obesity prevention and treatment. A secondary aim of the study is to establish a connection between benzoate exposure and biomarkers in urine that can be used to help treat obese patients.
Interventions
- OTHER Benzoic acid washout and exposure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2017-07-01 |
| Est. Completion | 2021-04-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03190785
The ClinicalTrials.gov registry entry for NCT03190785 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is East Carolina University, which has 58 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Benzoic acid washout and exposure is the first listed.
NCT03190785 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03190785 about?
NCT03190785 is a clinical study titled "Benzoates - an Obesogenic Endocrine Disrupting Chemical". The benzoic acid derivatives sodium and potassium benzoate are preservatives that are commonly added to food and beverages to inhibit microbial growth and prevent spoilage. In the US the major source of benzoate intake is beverages. Studies have shown that piglets or chicks fed low levels of benzoic...
What is the current status of trial NCT03190785?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2017-07-01. Estimated completion is 2021-04-01.
What interventions are being tested in trial NCT03190785?
The interventions under investigation include: Benzoic acid washout and exposure (OTHER).
Who is sponsoring clinical trial NCT03190785?
This trial is sponsored by East Carolina University, which has 58 total clinical trials registered on ClinicalTrials.gov.
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