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NCT03190785 · ClinicalTrials.gov registry record · NA
Benzoates - an Obesogenic Endocrine Disrupting Chemical
A NA study, sponsored by East Carolina University.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT03190785: Completed NA study, sponsored by East Carolina University.
NCT03190785 is a NA study that has completed, run by East Carolina University. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03190785, a NA study, has completed, sponsored by East Carolina University.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
The benzoic acid derivatives sodium and potassium benzoate are preservatives that are commonly added to food and beverages to inhibit microbial growth and prevent spoilage. In the US the major source of benzoate intake is beverages. Studies have shown that piglets or chicks fed low levels of benzoic acid have greater feed efficiency and gain more weight than control fed animals. It has also been shown that benzoic acid inhibits the release of a key metabolic hormone, leptin, from isolated adipocytes (fat cells). Inadequate leptin levels result in increased appetite, decreased metabolic rate, weight gain, insulin resistance and increased diabetes risk. The primary aim of the proposed research is to directly determine if benzoate consumption in human volunteers results in lower levels of leptin, decreased metabolic rate and increased insulin resistance. If so this would implicate benzoic acid as an obesogen and would help inform more effective approaches to obesity prevention and treatment. A secondary aim of the study is to establish a connection between benzoate exposure and biomarkers in urine that can be used to help treat obese patients.
Primary Outcome
Metabolic rate as measured by indirect calorimetry
Interventions
- OTHER Benzoic acid washout and exposure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2017-07-01 |
| Est. Completion | 2021-04-01 |
| Phase | NA |
What the finished NCT03190785 record still lists
NCT03190785 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Benzoic acid washout and exposure is the first listed.
NCT03190785 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03190785 about?
NCT03190785 is a clinical study titled "Benzoates - an Obesogenic Endocrine Disrupting Chemical". The benzoic acid derivatives sodium and potassium benzoate are preservatives that are commonly added to food and beverages to inhibit microbial growth and prevent spoilage. In the US the major source of benzoate intake is beverages. Studies have shown that piglets or chicks fed low levels of benzoic...
What is the current status of trial NCT03190785?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2017-07-01. Estimated completion is 2021-04-01.
What interventions are being tested in trial NCT03190785?
The interventions under investigation include: Benzoic acid washout and exposure (OTHER).
Who is sponsoring clinical trial NCT03190785?
This trial is sponsored by East Carolina University, which has 58 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03190785's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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