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NCT03179163 · ClinicalTrials.gov registry record · Phase 1
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
A Phase 1 study, sponsored by Penn State University.
- Terminated
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT03179163 is a Phase 1 study that was terminated before completion, run by Penn State University. The registered enrollment target is 10 participants.
The verdict
NCT03179163, a Phase 1 study, was terminated before completion, sponsored by Penn State University.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have poor results with medical treatment for hypertension. The researchers examine the impact of different classes of drugs that doctors use to treat high blood pressure (hypertension) on blood vessel remodeling. Some drugs that doctors prescribe for their patients contain a "sulfhydryl group" (a sulfur atom bonded to a hydrogen atom). Drugs that have the sulfhydryl group may reduce blood vessel remodeling more that drugs that do not. For this study, participants who have high blood pressure perform the experiments, take a drug for 16-weeks to lower blood pressure, and repeat the experiments. The researchers randomly assign one of three drugs to participants who have high blood pressure: a diuretic ("water pill"), a drug containing a sulfhydryl (SH) group, or a drug that does not contain a sulfhydryl group. Participants who do not have high blood pressure perform the experiments, but do not take any of the drugs. In some of our experiments, the researchers use a technique called "microdialysis" (MD). With MD, the researchers perfuse some research drugs into the skin on the forearm through tiny tubing that mimics capillaries. These MD drugs mimic or block substances the body naturally makes to control the small blood vessels in the skin. The drugs remain in nickel-sized areas around the tubing and do not go into the rest of the body. The researchers also analyze very small skin samples (skin biopsy) obtained from the forearm. Lastly, the researchers use a standard technique called "flow mediated dilation" (FMD) that uses blood pressure cuffs and ultrasound to look at the health of larger blood vessels in the body. FMD includes placing a small tablet of nitroglycerin under the tongue during part of the test.
Interventions
- DRUG Hydrochlorothiazide
- DRUG Captopril Pill
- DRUG Enalapril Pill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2016-07-20 |
| Est. Completion | 2022-12-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03179163
The ClinicalTrials.gov registry entry for NCT03179163 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Penn State University, which has 219 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Hydrochlorothiazide is the first listed.
NCT03179163 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03179163 about?
NCT03179163 is a clinical study titled "Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans". High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have poor results with medical treatment for hypertension. The researchers exa...
What is the current status of trial NCT03179163?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2016-07-20. Estimated completion is 2022-12-31.
What interventions are being tested in trial NCT03179163?
The interventions under investigation include: Hydrochlorothiazide (DRUG), Captopril Pill (DRUG), Enalapril Pill (DRUG).
Who is sponsoring clinical trial NCT03179163?
This trial is sponsored by Penn State University, which has 219 total clinical trials registered on ClinicalTrials.gov.
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