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NCT03166787 · ClinicalTrials.gov registry record · Phase 1
Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
A Phase 1 study, sponsored by Cedars-Sinai Medical Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
NCT03166787 is a Phase 1 study that was terminated before completion, run by Cedars-Sinai Medical Center. The registered enrollment target is 60 participants.
The verdict
NCT03166787, a Phase 1 study, was terminated before completion, sponsored by Cedars-Sinai Medical Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal. Cigarettes, cigars, medicinal nicotine, and e-cigarettes all acutely impair brachial artery endothelial function (flow-mediated dilation, FMD). Also, cigarettes cause both acute and chronic impairment in coronary endothelial function, but the comparative effects of hookah are unknown. Hookah tobacco is heated with burning charcoal. So, the smoke contains "tar" and nicotine plus charcoal combustion products. These include carbon monoxide (CO) and proatherogenic oxidants (especially carbon-rich nanoparticles) that the study team expected to impair endothelial function.
Interventions
- OTHER Cigarette
- OTHER Charcoal hookah
- OTHER E-coal hookah
- DRUG Carbon Monoxide inhalation
- OTHER Room Air inhalation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2017-08-15 |
| Est. Completion | 2020-10-15 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03166787
The ClinicalTrials.gov registry entry for NCT03166787 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cedars-Sinai Medical Center, which has 339 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Cigarette is the first listed.
NCT03166787 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03166787 about?
NCT03166787 is a clinical study titled "Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function". Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal....
What is the current status of trial NCT03166787?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2017-08-15. Estimated completion is 2020-10-15.
What interventions are being tested in trial NCT03166787?
The interventions under investigation include: Cigarette (OTHER), Charcoal hookah (OTHER), E-coal hookah (OTHER), Carbon Monoxide inhalation (DRUG), Room Air inhalation (OTHER).
Who is sponsoring clinical trial NCT03166787?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
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