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NCT03166787 · ClinicalTrials.gov registry record · Phase 1
Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
A Phase 1 study, sponsored by Cedars-Sinai Medical Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
NCT03166787: Clinical Trial Phase 1 study, sponsored by Cedars-Sinai Medical Center.
NCT03166787 is a Phase 1 study that was terminated before completion, run by Cedars-Sinai Medical Center. The registered enrollment target is 60 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03166787, a Phase 1 study, was terminated before completion, sponsored by Cedars-Sinai Medical Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal. Cigarettes, cigars, medicinal nicotine, and e-cigarettes all acutely impair brachial artery endothelial function (flow-mediated dilation, FMD). Also, cigarettes cause both acute and chronic impairment in coronary endothelial function, but the comparative effects of hookah are unknown. Hookah tobacco is heated with burning charcoal. So, the smoke contains "tar" and nicotine plus charcoal combustion products. These include carbon monoxide (CO) and proatherogenic oxidants (especially carbon-rich nanoparticles) that the study team expected to impair endothelial function.
Primary Outcome
the change in Myocardial Blood Flow between Baseline and post intervention.
Interventions
- OTHER Cigarette
- OTHER Charcoal hookah
- OTHER E-coal hookah
- DRUG Carbon Monoxide inhalation
- OTHER Room Air inhalation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2017-08-15 |
| Est. Completion | 2020-10-15 |
| Phase | Phase 1 |
Why NCT03166787 stopped before completion
NCT03166787 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 5 interventions - of which Cigarette is the first listed.
NCT03166787 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03166787 about?
NCT03166787 is a clinical study titled "Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function". Hookah (water pipe) smoking is a new global epidemic. The World Health Organization wants to prohibit all claims that hookah is less harmful than cigarettes and wants hookah products to bear the same warning labels as cigarettes. But there is little scientific evidence to substantiate this proposal....
What is the current status of trial NCT03166787?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2017-08-15. Estimated completion is 2020-10-15.
What interventions are being tested in trial NCT03166787?
The interventions under investigation include: Cigarette (OTHER), Charcoal hookah (OTHER), E-coal hookah (OTHER), Carbon Monoxide inhalation (DRUG), Room Air inhalation (OTHER).
Who is sponsoring clinical trial NCT03166787?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03166787's enrollment target sits among peer trials
60 831st of 2000 higher than 1,106 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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