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NCT03143543 · ClinicalTrials.gov registry record · Phase 1
Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder
A Phase 1 study, sponsored by Virginia Commonwealth University.
- Terminated
- Registry status
- Phase 1
- Development phase
- 171
- Enrollment target
NCT03143543: Clinical Trial Phase 1 study, sponsored by Virginia Commonwealth University.
NCT03143543 is a Phase 1 study that was terminated before completion, run by Virginia Commonwealth University. The registered enrollment target is 171 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (185% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03143543, a Phase 1 study, was terminated before completion, sponsored by Virginia Commonwealth University.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 171 participants
- Enrollment target
Study Summary
The purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in cocaine use disorder (CocUD) subjects and/or opioid use disorder.
Primary Outcome
To determine target engagement by lorcaserin in a cocaine-Stroop and/or opioid-Stroop cue-reactivity fMRI task in cocaine use disorder (CocUD) and/or Opioid Use Disorder Subjects
Interventions
- DRUG Group A Lorcaserin (10mg)
- DRUG Group A2 Lorcaserin (20 mg)
- OTHER Group B Parallel Placebo
- OTHER Group B2 Parallel Placebo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2015-07 |
| Est. Completion | 2019-12-06 |
| Phase | Phase 1 |
Why NCT03143543 stopped before completion
NCT03143543 is an interventional study that assigns participants to a tested intervention. The registered 171 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (185% higher).
The record links to 0 conditions, and to 4 interventions - of which Group A Lorcaserin (10mg) is the first listed.
NCT03143543 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03143543 about?
NCT03143543 is a clinical study titled "Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder". The purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in cocaine use disorder (CocUD) subjects and/or opioid use disorder.
What is the current status of trial NCT03143543?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 171 participants. The study started on 2015-07. Estimated completion is 2019-12-06.
What interventions are being tested in trial NCT03143543?
The interventions under investigation include: Group A Lorcaserin (10mg) (DRUG), Group A2 Lorcaserin (20 mg) (DRUG), Group B Parallel Placebo (OTHER), Group B2 Parallel Placebo (OTHER).
Who is sponsoring clinical trial NCT03143543?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03143543's enrollment target sits among peer trials
171 324th of 2000 higher than 1,676 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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