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ACTIVE NOT RECRUITING Phase 2

Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

NCT03141684 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well atezolizumab or atezolizumab plus bevacizumab works in treating patients with alveolar soft part sarcoma that has not been treated, has spread from where it started to other places in the body (advanced) and cannot be removed by surgery (unresectable). Atezolizumab works by unblocking the immune system, allowing the immune system cells to recognize and then attack tumor cells. Bevacizumab works by controlling the growth of new blood vessels. Giving atezolizumab alone or atezolizumab with bevacizumab may shrink the cancer.

Interventions

  • PROCEDURE Biospecimen Collection
  • PROCEDURE Computed Tomography
  • DRUG Atezolizumab
  • BIOLOGICAL Bevacizumab

Study Locations (20)

Connecticut

  • Smilow Cancer Hospital-Derby Care Center — Derby
  • Smilow Cancer Hospital Care Center-Fairfield — Fairfield
  • Smilow Cancer Hospital Care Center - Guilford — Guilford
  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford
  • Smilow Cancer Center/Yale-New Haven Hospital — New Haven
  • Yale University — New Haven
  • Yale-New Haven Hospital North Haven Medical Center — North Haven
  • Smilow Cancer Hospital-Orange Care Center — Orange
  • Smilow Cancer Hospital-Torrington Care Center — Torrington
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull
  • Smilow Cancer Hospital-Waterbury Care Center — Waterbury
  • Smilow Cancer Hospital Care Center - Waterford — Waterford

California

  • Keck Medicine of USC Buena Park — Buena Park
  • Keck Medicine of USC Koreatown — Los Angeles
  • Los Angeles General Medical Center — Los Angeles
  • USC / Norris Comprehensive Cancer Center — Los Angeles
  • USC Norris Oncology/Hematology-Newport Beach — Newport Beach
  • Keck Medical Center of USC Pasadena — Pasadena
  • University of California Davis Comprehensive Cancer Center — Sacramento

Georgia

  • Emory University Hospital Midtown — Atlanta

Trial Details

FieldValue
Enrollment Target 63 participants
Start Date 2017-04-25
Est. Completion 2026-10-31
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03141684

The ClinicalTrials.gov registry entry for NCT03141684 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Metastatic Alveolar Soft Part Sarcoma appearing as the primary indexed condition, and to 4 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03141684 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Connecticut, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03141684 about?

NCT03141684 is a clinical study titled "Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma". This phase II trial studies how well atezolizumab or atezolizumab plus bevacizumab works in treating patients with alveolar soft part sarcoma that has not been treated, has spread from where it started to other places in the body (advanced) and cannot be removed by surgery (unresectable). Atezolizum...

What is the current status of trial NCT03141684?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 63 participants. The study started on 2017-04-25. Estimated completion is 2026-10-31.

What conditions does trial NCT03141684 study?

This clinical trial studies the following conditions: Metastatic Alveolar Soft Part Sarcoma, Unresectable Alveolar Soft Part Sarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03141684?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Computed Tomography (PROCEDURE), Atezolizumab (DRUG), Bevacizumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03141684?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03141684 being conducted?

This trial has 20 study locations across California, Connecticut, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial