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NCT03123107 · ClinicalTrials.gov registry record · Phase 1
Vitamin C in Cardiac Surgery Patients
A Phase 1 study, sponsored by Geisinger Clinic.
- Completed
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
NCT03123107: Completed Phase 1 study, sponsored by Geisinger Clinic.
NCT03123107 is a Phase 1 study that has completed, run by Geisinger Clinic. The registered enrollment target is 6 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03123107, a Phase 1 study, has completed, sponsored by Geisinger Clinic.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
Study Summary
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery that increases the incidence of stroke, kidney injury and death. Vitamin C has been shown to decrease the incidence of POAF follow cardiac surgery, but the optimal dose has not been identified. With this project, the investigators plan to gather pharmacokinetic and dose-response data for vitamin C in the cardiac surgery population. The investigators plan to conduct a small interventional pilot study investigating the pharmacokinetics and pharmacodynamics of Vitamin C in patients undergoing coronary artery bypass graft (CABG) surgery. Patients enrolled will receive an intravenous dose of Vitamin C the day before surgery and the day after. Patients will have blood samples obtained with each dose for analysis of vitamin C concentrations and several biomarkers of oxidative stress. Analysis of samples will be performed within the Department of Pharmaceutical Sciences at Wilkes University.
Primary Outcome
Maximum serum concentration of ascorbate obtained after drug administration.
Interventions
- DRUG Ascorbic Acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2017-07-06 |
| Est. Completion | 2019-05-31 |
| Phase | Phase 1 |
What the finished NCT03123107 record still lists
NCT03123107 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 1 intervention - of which Ascorbic Acid is the first listed.
NCT03123107 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03123107 about?
NCT03123107 is a clinical study titled "Vitamin C in Cardiac Surgery Patients". Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery that increases the incidence of stroke, kidney injury and death. Vitamin C has been shown to decrease the incidence of POAF follow cardiac surgery, but the optimal dose has not been identified. With this proj...
What is the current status of trial NCT03123107?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2017-07-06. Estimated completion is 2019-05-31.
What interventions are being tested in trial NCT03123107?
The interventions under investigation include: Ascorbic Acid (DRUG).
Who is sponsoring clinical trial NCT03123107?
This trial is sponsored by Geisinger Clinic, which has 107 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03123107's enrollment target sits among peer trials
6 1974th of 2000 higher than 12 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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