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NCT03114488 · ClinicalTrials.gov registry record · NA
Modulating Human Cortical Plasticity With Transcranial Electrical Stimulation
A NA study, sponsored by University of Minnesota.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
NCT03114488 is a NA study that has completed, run by University of Minnesota. The registered enrollment target is 41 participants.
The verdict
NCT03114488, a NA study, has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
Study Summary
Experience dependent plasticity is a fundamental property of the brain. It allows neural systems to adapt in response to environmental input and subserves the vital functions of learning and memory. Deficits in plasticity are also thought play a causal role in the pathophysiology of several psychiatric disorders, specifically schizophrenia (SZ). Treatments that can probe or even enhance plasticity have potential to be of great clinical and research value. Non-invasive neuromodulation via transcranial direct current stimulation (tDCS) is a promising method for modulating neural plasticity. tDCS delivers low-intensity direct current to cortical areas, thereby facilitating or inhibiting neural activity in a polarity specific manner. Due to its low cost and safety, tDCS has been employed in a wide variety of studies, but much remains unknown regarding its mechanism of action in humans. Experiments carried out in animal and tissue models indicate that tDCS modulates synaptic plasticity mechanisms of long term potentiation and depression (LTP/D), however, these findings have never been translated to human subjects, limiting the practical utility of the research. Recently developed electroencephalographic (EEG) based measures now allow the interrogation of synaptic plasticity non-invasively in humans, making it possible to explore the effects of tDCS on human brain plasticity.
Interventions
- DEVICE tDCS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2017-12-01 |
| Est. Completion | 2018-10-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03114488
The ClinicalTrials.gov registry entry for NCT03114488 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Minnesota, which has 966 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which tDCS is the first listed.
NCT03114488 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03114488 about?
NCT03114488 is a clinical study titled "Modulating Human Cortical Plasticity With Transcranial Electrical Stimulation". Experience dependent plasticity is a fundamental property of the brain. It allows neural systems to adapt in response to environmental input and subserves the vital functions of learning and memory. Deficits in plasticity are also thought play a causal role in the pathophysiology of several psychiat...
What is the current status of trial NCT03114488?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2017-12-01. Estimated completion is 2018-10-05.
What interventions are being tested in trial NCT03114488?
The interventions under investigation include: tDCS (DEVICE).
Who is sponsoring clinical trial NCT03114488?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
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