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NCT03077711 · ClinicalTrials.gov registry record · Phase 4
Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs
A Phase 4 study, sponsored by Endeavor Health.
- Completed
- Registry status
- Phase 4
- Development phase
- 92
- Enrollment target
NCT03077711 is a Phase 4 study that has completed, run by Endeavor Health. The registered enrollment target is 92 participants.
The verdict
NCT03077711, a Phase 4 study, has completed, sponsored by Endeavor Health.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 92 participants
- Enrollment target
Study Summary
Several methods are available for use in the prevention of recurrent urinary tract infections (UTIs) over the past few decades. These methods include suppressive antibiotics, estrogen cream, methenamine hippurate, d-mannose, cranberry, probiotics, and vitamin C. Of these, the majority of the literature is in favor of use of suppressive antibiotics for preventing UTIs. However, this data is now about 10 years old. Increasing use of antibiotics over the years has lead to increased resistance of bacteria. In addition, long-term antibiotic use has several adverse effects, some life-threatening. There is recent literature evaluating the use of several of the alternatives to suppressive antibiotics with mixed results. A comparative study of the efficacy of methenamine hippurate to suppressive antibiotics is lacking in the current literature. Several early partly-randomized trials done with methenamine hippurate have shown promising results, but are only as recent as 1987. The primary objective of this prospective, randomized study is to determine whether there is a significant difference in the prevention of recurrent UTIs when given either methenamine hippurate or daily suppressive antibiotics. The secondary objective of this study is to determine how well patients are able to tolerate each of these medications and what adverse effects are observed in a given 1 year time period. The long-term goals of this study are to find an alternative to using suppressive antibiotics, potentially with a lower adverse effect profile and less of the dangers of long term antibiotic use. Finding an alternative to suppressive antibiotics would also tackle the issue of antibiotic resistance.
Interventions
- DRUG Trimethoprim
- DRUG Methenamine hippurate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 92 participants |
| Start Date | 2016-06 |
| Est. Completion | 2019-06-21 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03077711
The ClinicalTrials.gov registry entry for NCT03077711 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 92 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Endeavor Health, which has 94 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Trimethoprim is the first listed.
NCT03077711 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03077711 about?
NCT03077711 is a clinical study titled "Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs". Several methods are available for use in the prevention of recurrent urinary tract infections (UTIs) over the past few decades. These methods include suppressive antibiotics, estrogen cream, methenamine hippurate, d-mannose, cranberry, probiotics, and vitamin C. Of these, the majority of the literat...
What is the current status of trial NCT03077711?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 92 participants. The study started on 2016-06. Estimated completion is 2019-06-21.
What interventions are being tested in trial NCT03077711?
The interventions under investigation include: Trimethoprim (DRUG), Methenamine hippurate (DRUG).
Who is sponsoring clinical trial NCT03077711?
This trial is sponsored by Endeavor Health, which has 94 total clinical trials registered on ClinicalTrials.gov.
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