Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor
NCT03069469 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, open-label Phase 1/2 study of vimseltinib in patients with malignant solid tumors and tenosynovial giant cell tumor (TGCT). There will be 2 distinct parts in this study: Dose Escalation (Phase 1) and Expansion (Phase 2). Phase 1 will enroll both malignant solid tumor and TGCT patients. Phase 2 will comprise two cohorts (Cohort A and Cohort B) and will only enroll TGCT patients.
Conditions Studied
Interventions
- DRUG Vimseltinib
Study Locations (20)
Other
- Peter MacCallum Cancer Centre — Melbourne
- Princess Margaret Cancer Center — Toronto
- Centre Leon Berard — Lyon
- Gustave Roussy Cancer Campus Grand Paris — Paris
- IRCCS Istituto Ortopedico Rizzoli — Bologna
- Fondazione IRCCS Istituto Nazionale Dei Tumori — Milan
- Istituto Nazionale dei Tumori — Milan
- Regina Elena National Cancer Institute — Rome
- Leiden University Medical Center — Leiden
- M. Sklodowska-Curie Memorial Cancer Center — Warsaw
Florida
- Mayo Clinic — Jacksonville
- University of Miami — Miami
Oregon
- OHSU — Portland
- Oregon Health & Science University — Portland
California
- Stanford Cancer Institute — Palo Alto
Colorado
- University of Colorado - Denver — Denver
Massachusetts
- Dana Farber — Boston
New York
- MSKCC — New York
Tennessee
- Sarah Cannon Research Institute — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2017-02-16 |
| Est. Completion | 2028-08 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03069469
The ClinicalTrials.gov registry entry for NCT03069469 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Deciphera Pharmaceuticals, which has 42 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Advanced Malignant Neoplasm appearing as the primary indexed condition, and to 1 intervention — of which Vimseltinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03069469 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, Florida, Oregon. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03069469 about?
NCT03069469 is a clinical study titled "Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor". This is a multicenter, open-label Phase 1/2 study of vimseltinib in patients with malignant solid tumors and tenosynovial giant cell tumor (TGCT). There will be 2 distinct parts in this study: Dose Escalation (Phase 1) and Expansion (Phase 2). Phase 1 will enroll both malignant solid tumor and TGCT ...
What is the current status of trial NCT03069469?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 120 participants. The study started on 2017-02-16. Estimated completion is 2028-08.
What conditions does trial NCT03069469 study?
This clinical trial studies the following conditions: Advanced Malignant Neoplasm, Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03069469?
The interventions under investigation include: Vimseltinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03069469?
This trial is sponsored by Deciphera Pharmaceuticals, which has 42 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03069469 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Massachusetts, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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