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NCT03067701 · ClinicalTrials.gov registry record · Phase 1
Effects of Carbon Monoxide Breathing on Blood Vessel Function
A Phase 1 study, sponsored by Cedars-Sinai Medical Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT03067701: Completed Phase 1 study, sponsored by Cedars-Sinai Medical Center.
NCT03067701 is a Phase 1 study that has completed, run by Cedars-Sinai Medical Center. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03067701, a Phase 1 study, has completed, sponsored by Cedars-Sinai Medical Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah smoking, augments endothelial function, thus implicating CO as the major endothelial vasodilator substance in hookah smoke. Rationale: Our group has demonstrated (PRO36547) that in contrast to cigarette smoking, hookah smoking (tobacco heated with charcoal) acutely augments, rather than impairs, brachial artery FMD. Importantly, our data strongly implicate-but do not prove-that the augmentation in FMD is caused by CO. Therefore; the investigators would like to extend the scientific priority of this work by directly investigating cause and effect of CO breathing (similar levels than ones obtained after hookah smoking) on brachial artery FMD.
Primary Outcome
assessment of endothelial function measured by brachial artery flow-mediated dilation after 30-40 minutes of carbon monoxide adminstration
Interventions
- DRUG Carbon Monoxide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2017-06-23 |
| Est. Completion | 2019-03-01 |
| Phase | Phase 1 |
What the finished NCT03067701 record still lists
NCT03067701 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 1 intervention - of which Carbon Monoxide is the first listed.
NCT03067701 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03067701 about?
NCT03067701 is a clinical study titled "Effects of Carbon Monoxide Breathing on Blood Vessel Function". In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah smoking, augments endothelial function, thus implicating CO as the major endo...
What is the current status of trial NCT03067701?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2017-06-23. Estimated completion is 2019-03-01.
What interventions are being tested in trial NCT03067701?
The interventions under investigation include: Carbon Monoxide (DRUG).
Who is sponsoring clinical trial NCT03067701?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03067701's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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